Title:Advances in Exosomal microRNAs and Proteins in Ovarian Cancer
Diagnosis, Prognosis, and Treatment
Volume: 23
Issue: 6
Author(s): Tiansheng Qin*, Fan Chen, Jiaojiao Zhu, Yaoyao Ding and Qianqian Zhang
Affiliation:
- The First Clinical Medical College of Gansu University of Chinese Medicine, Lanzhou, Gansu, 730000,
China
- Gansu Provincial Hospital, Lanzhou, Gansu, 730000, China
Keywords:
Exosomes, microRNAs, proteins, ovarian cancer, diagnosis, prognosis, therapy, drug resistance.
Abstract: Late diagnosis, postoperative recurrence, and chemotherapy resistance are
the main causes of the high mortality rate in ovarian cancer (OC). Understanding the
molecular mechanisms in the pathogenesis and progression of OC may contribute to
discovering new tumor biomarkers and therapeutic targets for OC. Exosomes are small
extracellular vesicles derived from different types of cells that carry cargos, including
nucleic acids, proteins, and lipids, and are pivotal mediators of intercellular
communication in the tumor microenvironment. There is emerging evidence that
exosomal proteins and nucleic acids play pivotal roles in facilitating the progression and
drug resistance of OC. Identification of these factors may aid in the future diagnosis of
OC. Furthermore, they also have promising value as OC therapeutic targets that can
improve the prognosis. In the current review, we summarize the progress of exosomal
research in OC, especially highlighting the most updated roles of exosomal microRNAs
and proteins in the diagnosis, prognosis, therapy, and drug resistance of OC in order to
facilitate future studies in this area.
