Title:Effect of Simultaneous Dual-Task Training on Regional Cerebral Blood
Flow in Older Adults with Amnestic Mild Cognitive Impairment
Volume: 19
Issue: 6
关键词:
无症状轻度认知障碍，双任务训练，局部脑血流，单光子发射计算机断层扫描，逆转，转换，非随机对照试验。
摘要:
Background: No previous study has examined the effect of dual-task training using changes
in regional cerebral blood flow (rCBF) using single-photon emission computed tomography (SPECT) as
an outcome.
Objective: This study aimed to examine the effects of simultaneous dual-task training of exercise and
cognitive tasks on rCBF using SPECT in older adults with amnestic mild cognitive impairment (aMCI).
Methods: In this non-randomized control trial, 40 older adults with aMCI participated from May 2016 to
April 2018. Outpatients in the intervention group (n = 22) underwent 24 sessions (12 months) of dualtask
training twice a month for 60 mins per session. Participants in the control group (n = 18) continued
to have regular outpatient visits. The primary outcome was rCBF at baseline and after 12 months, which
was compared in each group using the two-sample t-test. The secondary outcomes were the rate of reversion
and conversion from aMCI after 12 months.
Results: Of the 22 participants in the intervention group, six dropped out; therefore, 16 were included in
the analysis. The intervention group showed more significant increases in rCBF in multiple regions, including
the bilateral frontal lobes, compared with the control group. However, the rates of reversion or
conversion from mild cognitive impairment (MCI) were not significantly different.
Conclusion: Dual-task training for older adults with aMCI increased rCBF in the frontal gyrus but did
not promote reversion from MCI to normal cognition. Future intervention studies, such as follow-up examinations
after the intervention, are warranted to consider long-term prognosis.
