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摘要
青春期始于下丘脑中促性腺激素释放激素 (GnRH) 的持续和不断增长的脉动分泌,然后是下丘脑-垂体-性腺 (HPG) 轴的激活。许多因素涉及青春期启动,其异常可能来自这些调节器的功能障碍。Makorin RING指蛋白3(MKRN3)抑制GnRH的分泌,在青春期发病过程中起着不可或缺的作用,MKRN3突变是中枢性性早熟(CPP)最常见的遗传原因。最近,越来越多的研究揭示了MKRN3在青春期启动和CPP发生的功能机制。本文主要综述了MKRN3在青春期发病中的作用及其基础机制的研究进展,有助于进一步了解青春期发病的确切机制和CPP的发病机制。
关键词: 马科林无名指蛋白3,MKRN3,青春期开始,中枢性性早熟,CPP,GnRH
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