Title:The Key Roles of Makorin RING Finger Protein 3 (MKRN3) During
the Development of Pubertal Initiation and Central Precocious
Puberty (CPP)
Volume: 23
Issue: 7
Author(s): Jiang Liu, Tangluo Li, Mindan Peng, Min Luo, Zihao Gui, Shuanglian Long*, Zhongcheng Mo*Weiguo He*
Affiliation:
- Clinical Anatomy and Reproductive Medicine Application Institute, Hengyang Medical School, University of
South China, Hengyang 421001, China
- Guangxi Key
Laboratory of Diabetic Systems Medicine, Guilin Medical University, Guilin 541000, Guangxi, China
- Clinical Anatomy and Reproductive Medicine Application Institute, Hengyang Medical School, University of
South China, Hengyang 421001, China
Keywords:
Makorin RING finger protein 3, MKRN3, Puberty initiation, Central precocious puberty, CPP, GnRH.
Abstract: Puberty is initiated from the continuous and growing pulsatile secretion of
gonadotropin-releasing hormone (GnRH) in the hypothalamus and then the activation of
the hypothalamic-pituitary-gonadal (HPG) axis. Numerous factors involve pubertal
initiation, whose abnormality may come from the dysfunction of these regulators.
Makorin RING finger protein 3 (MKRN3) inhibits the secretion of GnRH and plays
indispensable roles during the development of pubertal onset, and mutations of MKRN3
showed the commonest genetic cause of central precocious puberty (CPP). Recently,
growing studies have revealed the functional mechanisms of MKRN3 in the pubertal
initiation and the occurrence of CPP. In this review, we mainly summarized the research
advances on the roles of MKRN3 in the development of pubertal onset and their
underpinning mechanisms, contributing to a better understanding of the precise
mechanisms of pubertal initiation and the pathogenesis of CPP.
