Title:Therapeutic Approaches for Combating Aspergillus Associated Infection
Volume: 23
Issue: 16
关键词:
曲霉菌，侵袭性曲霉病，多烯类，唑类，棘白菌素类，新型药物。
摘要: Now-a-days fungal infection emerges as a significant problem to healthcare management
systems due to high frequency of associated morbidity, mortality toxicity, drug-drug interactions,
and resistance of the antifungal agents. Aspergillus is the most common mold that cause infection in
immunocompromised hosts. It's a hyaline mold that is cosmopolitan and ubiquitous in nature.
Aspergillus infects around 10 million population each year with a mortality rate of 30-90%.
Clinically available antifungal formulations are restricted to four classes (i.e., polyene, triazole,
echinocandin, and allylamine), and each of them have their own limitations associated with the
activity spectrum, the emergence of resistance, and toxicity. Consequently, novel antifungal agents
with modified and altered chemical structures are required to combat these invasive fungal
infections. To overcome these limitations, there is an urgent need for new antifungal agents that can
act as potent drugs in near future. Currently, some compounds have shown effective antifungal
activity. In this review article, we have discussed all potential antifungal therapies that contain old
antifungal drugs, combination therapies, and recent novel antifungal formulations, with a focus on
the Aspergillus associated infections.
