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Review Article

纳米医学方法能否为酪氨酸激酶抑制剂的疗效提供优势？

卷 30, 期 13, 2023

发表于: 14 September, 2022

页: [1482 - 1501] 页: 20

弟呕挨: 10.2174/0929867329666220618162303

价格: $65

摘要

酪氨酸激酶抑制剂（TKI）是治疗各种癌症的有效药物分子。纳米医学干预和方法不仅可以为TKI提供承载能力，还可以潜在地针对肿瘤特异性环境甚至细胞区室。因此，纳米启发的药物递送系统可以通过增强肿瘤可用性来提高药物的功效，从而产生更大的疗效并减少副作用。已经开发了各种纳米系统来输送TKI以增强癌症的治疗，每种系统都有自己的制备方法和物理化学特性。因此，本综述将讨论纳米干预对联合治疗、剂量减少和更大潜在治疗结局的适用性。强调了单个纳米系统，重点是已开发的系统及其对各种癌细胞系和模型的功效。

关键词: 酪氨酸激酶抑制剂，纳米系统，癌症，细胞系，纳米颗粒，纳米胶束

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