Title:Resveratrol in Cancer Treatment with a Focus on Breast Cancer
Volume: 16
Author(s): Hamed Kowsari, Amirhossein Davoodvandi, Fatemeh Dashti, Seyed Mohamad Ali Mirazimi, Zahra Razaghi Bahabadi, Michael Aschner, Amirhossein Sahebkar, Hamid Reza Gilasi*, Michael R Hamblin*Hamed Mirzaei*
Affiliation:
- Department of Epidemiology and Biostatistics, Faculty of Health, Kashan University of Medical Sciences, Kashan, Iran
- Faculty of Health Science, Laser Research
Centre, University of Johannesburg, Doornfontein 2028, South Africa
- Research Center for Biochemistry and Nutrition
in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, I.R., Iran
Keywords:
Breast cancer, resveratrol, cancer therapy, phytochemicals, signaling pathways, chemotherapy.
Abstract: Acute liver injury (ALI) is a critical and fatal disorder associated with excessive Although
considerable advances have been made in the early diagnosis and treatment of breast
cancer, it is still one of the major causes of global cancer-related death in women over the last
several decades. Phytochemicals have been shown to be promising agents in the prevention and
treatment of breast cancer. Resveratrol is an important plant-derived polyphenolic compound
with a variety of potent biological activities. It has been suggested that resveratrol can be used
to prevent and treat various types of cancer, including breast cancer. Resveratrol can affect numerous
signaling pathways in vitro, leading to the induction of cell cycle arrest and apoptosis,
suppression of proliferation, reduction of inflammatory responses, and the inhibition of angiogenesis
and metastasis. Nevertheless, studies of resveratrol in animal models of breast cancer
have so far been disappointing.
