Title:A Concise Review of Common Plant-derived Compounds as a Potential
Therapy for Alzheimer's Disease and Parkinson's Disease: Insight into
Structure-Activity-Relationship
Volume: 22
Issue: 7
Author(s): Suchitra Nishal, Parmita Phaugat, Jyoti Bazaad, Rubal Dhaka, Sarita Khatkar, Anurag Khatkar*, Maryam Khayatkashani, Pooyan Alizadeh, Shima Motavalli Haghighi, Mohammad Mehri and Hamid Reza Khayat Kashani*
Affiliation:
- Department of Pharmaceutical Sciences, Maharshi Dayanand University,
Rohtak, India
- Department of Neurosurgery, Faculty of Neurosurgery, Shahid Beheshti University of Medical Sciences,
Tehran, Iran
Keywords:
Alzheimer’s disease, Parkinson’s disease, neurodegenerative, oxidative stress, neuroprotective, cholinesterase inhibitors.
Abstract: Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the two most common neurological
illnesses that affect people in their later years. Memory loss is the hallmark of Alzheimer’s disease,
while dyskinesia, or loss of mobility, is associated with muscle rigidity and tremors in PD. Both
diseases are unrelated, however, they do have a few similarities associated with extrapyramidal abnormalities,
particularly stiffness, which has been linked to concomitant PD in many AD patients. Increased
levels of IL-1, IL-6, and TNF in the AD and PD patients can be regarded as evidence of systemic
inflammation associated with each of these neurodegenerative disorders. One of the primary
variables in the progression of neurodegenerative disorders is oxidative stress. Many medicinal plants
and their secondary metabolites have been claimed to be able to help people with neurodegenerative
disorders like AD and PD. Anti-inflammatory, antioxidant, antiapoptotic, monoamine oxidase inhibition,
acetylcholinesterase, and neurotrophic pursuits are among the major mechanisms identified by
which phytochemicals exert their neuroprotective effects and potential maintenance of neurological
health in old age. In regard to neurodegenerative disorders, numerable plant-based drugs like alkaloids,
iridoids, terpenes, and flavones are employed for the treatment. Structure-activity relationships
(SAR) and quantitative structure-activity relationships (QSAR) are used to investigate the link between
bioactivity and the chemical configuration of substances. The SAR and QSAR of natural plant
components employed in AD and PD are discussed in the current review.
