Title:Nano-Based Drug Delivery of Anticancer Chemotherapeutic Drugs Targeting
Breast Cancer
Volume: 18
Issue: 3
Author(s): Akanksha Behl and Anil K. Chhillar*
Affiliation:
- Centre for Biotechnology, Maharshi Dayanand University, Rohtak, Haryana-124001, India
Keywords:
Chemotherapeutic drugs, breast cancer, targeted delivery, nanoparticles, NPs-mediated drug delivery, Breast malignancy.
Abstract:
Background: Chemotherapeutic drugs are principally intended to treat breast cancer.
However, sooner or later, tumor drug resistance developed. These chemo drugs are effective but with
numerous side effects. Breast cancer care may be extremely difficult since recurring cancer is frequently
pre-treated with powerful agents. Cancer cells acquire high resistance to earlier therapies,
necessitating alternative and more powerful drugs. Nanoparticles (NPs) as a medication delivery
technology can overcome medication resistance in breast cancer and significantly reduce the effective
dose. The off-targeted nature of chemo drugs can be resolved by encapsulating or attaching
chemo drugs in nanocarriers, specifically targeting breast cancer cells.
Objectives: This review highlights various chemo drugs for breast cancer and their encapsulation or
bioconjugation with nanoparticles for its targeted delivery.
Conclusion: Nanoparticles may subsist valuable abet in breast cancer management in this regard.
Given that traditional chemotherapy approaches have been demonstrated to have several side effects
and defects during treatment, the NPs-mediated drug delivery mechanism is a possible contender for
replacement as a new technique.