Title:A Mini-Review on the Synthesis of Substituted Isatins: From Early Approaches
to Recent Advances with a Specific Focus on Sulfamoyl and
Amino Derivatives
Volume: 21
Issue: 1
Author(s): Asu Büşra Temizer*, Taha Koulani, Özge Soylu Eter and Nilgun Karali
Affiliation:
- Institute of Health Sciences
and Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Istanbul
University, Istanbul, Turkey
- Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Istanbul University,
Istanbul, Turkey
Keywords:
2-indolinones, 5-aminoisatins, 5-sulfamoylisatins, heterocycles, indoles, isatins, synthesis.
Abstract: As a member of heterocyclic compounds, indole possesses a diverse set of biological activities.
Studies on the structure-activity relationship of 2-indolinones have shown that they are important
bioactive compounds in the field of pharmaceutical chemistry. Isatin and structures bearing isatin scaffold
are derivatives of indole, which have shown to be of biological and pharmacological significance.
This review focuses on different ways of obtaining compounds containing isatin structure, considering
both earlier and recent methods of synthesis. The syntheses given herein were grouped into three categories,
syntheses using anilines as their starting substance, synthetic methods based on the oxidation of
indoles, and finally, due to the extensive research going on 5-substituted isatins and their possible
pharmacological efficacy, pathways for synthesizing 5-amino and 5-sulfamoylisatins were gathered to
underline the importance of 2-indolinone and isatin derivatives as prospective therapeutic compounds
in current and future drug discovery studies.