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Mini-Reviews in Medicinal Chemistry

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ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

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Systematic Review Article

The Role of Sesamin in Targeting Neurodegenerative Disorders: A Systematic Review

Author(s): Mohammad Amin Ghaderi, Seyed Ahmad Emami, Mahla Daliri Beirak Olia and Behjat Javadi*

Volume 23, Issue 6, 2023

Published on: 23 August, 2022

Page: [756 - 770] Pages: 15

DOI: 10.2174/1389557522666220523112027

Price: $65

Open Access Journals Promotions 2
Abstract

Background: Neurodegenerative Diseases (NDs) are characterized by progressive neuronal deterioration as a result of several pathogenesis mechanisms. Phytochemicals, including sesamin with multitarget activities, have been studied widely.

Objective: In this review, we aim to survey the neuroprotective effects of sesamin on NDs and its mechanisms of action.

Methods: Searching GoogleScholar, PubMed, and Science Direct databases, we reviewed original English language articles on sesamin effects against NDs, specifically Alzheimer’s Disease (AD) and Parkinson's Disease (PD), either in vivo or in vitro settings, with no time limitation.

Results: Sesamin has been reported to interfere with NDs progression through its antioxidative, antiinflammatory, and antiapoptotic actions in most of the retrieved studies. Sesamin also can prevent amyloid-β aggregation in AD models and elevate dopamine levels in PD-induced models.

Conclusion: The results of this study revealed the beneficial effects of sesamin in the prevention and management of NDs, including AD and PD; however, no clinical data supporting these effects in humans is available, which highlights the need for designing clinical trials to evaluate the efficacy, proper dosage, pharmacokinetics aspects, and possible side effects of sesamin in humans.

Keywords: Sesamin, neurodegenerative disease, alzheimer’s disease, parkinson's disease, natural products, systematic review.

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