Title:The Role of Sesamin in Targeting Neurodegenerative Disorders: A Systematic
Review
Volume: 23
Issue: 6
Author(s): Mohammad Amin Ghaderi, Seyed Ahmad Emami, Mahla Daliri Beirak Olia and Behjat Javadi*
Affiliation:
- Department of Traditional Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
Keywords:
Sesamin, neurodegenerative disease, alzheimer’s disease, parkinson's disease, natural products, systematic review.
Abstract:
Background: Neurodegenerative Diseases (NDs) are characterized by progressive neuronal
deterioration as a result of several pathogenesis mechanisms. Phytochemicals, including sesamin with
multitarget activities, have been studied widely.
Objective: In this review, we aim to survey the neuroprotective effects of sesamin on NDs and its
mechanisms of action.
Methods: Searching GoogleScholar, PubMed, and Science Direct databases, we reviewed original
English language articles on sesamin effects against NDs, specifically Alzheimer’s Disease (AD) and
Parkinson's Disease (PD), either in vivo or in vitro settings, with no time limitation.
Results: Sesamin has been reported to interfere with NDs progression through its antioxidative, antiinflammatory,
and antiapoptotic actions in most of the retrieved studies. Sesamin also can prevent
amyloid-β aggregation in AD models and elevate dopamine levels in PD-induced models.
Conclusion: The results of this study revealed the beneficial effects of sesamin in the prevention and
management of NDs, including AD and PD; however, no clinical data supporting these effects in humans
is available, which highlights the need for designing clinical trials to evaluate the efficacy, proper
dosage, pharmacokinetics aspects, and possible side effects of sesamin in humans.