![conference banner](/images/conference-banner.jpeg)
摘要
简介: MicroRNA(miRNA)是一组小的非编码RNA(ncRNA),通过结合和降解其靶mRNA来控制基因的表达。miRNA可以作为各种癌症中可能的肿瘤抑制因子或癌基因。最近,miRNA作为不同疾病的生物标志物(预后和诊断)的应用引起了广泛关注。miRNA以稳定的形式存在于几种生物材料中,包括组织、血浆和血清。在血清、血液、组织和其他体液中对miRNA进行无创且易于筛选以及可接受的稳定性使microRNA成为人类恶性肿瘤中生物标志物的明显因素。 材料和方法:在本综述中,我们检索了一些在线数据库,如Web of Science,Embase和PubMed,以找到截至2021年底的合格稿件。 结果:这些分子的异常表达与许多疾病的发病率有关,如癌症。因此,它们是非侵入性肿瘤预后和诊断的分子工具的候选者。在目前的研究中,我们引入了重要的miRNA,可用作肺癌患者的预后和诊断标志物。 结论:我们总结了与肺部患者诊断和预后相关的关键miRNA的最新报道
关键词: 肺癌,miRNA,生物标志物,诊断,预后,NSCLC
[http://dx.doi.org/10.1080/07357907.2017.1416393] [PMID: 29336624]
[http://dx.doi.org/10.2174/1871520618666180808125459] [PMID: 30088452]
[PMID: 31890049]
[http://dx.doi.org/10.3390/ijms20071611] [PMID: 30935143]
[http://dx.doi.org/10.1158/0008-5472.CAN-04-0637] [PMID: 15172979]
[http://dx.doi.org/10.1182/blood-2012-12-469833] [PMID: 24493669]
[http://dx.doi.org/10.15171/bi.2019.03] [PMID: 30788256]
[http://dx.doi.org/10.2147/OTT.S249268] [PMID: 32753896]
[http://dx.doi.org/10.3892/or.2015.3895] [PMID: 25846246]
[http://dx.doi.org/10.3892/ol.2016.4577] [PMID: 27347142]
[http://dx.doi.org/10.3892/ol.2018.8595] [PMID: 29928380]
[http://dx.doi.org/10.1186/s12957-015-0607-5] [PMID: 26048406]
[http://dx.doi.org/10.1016/j.biopha.2019.108648] [PMID: 30780105]
[http://dx.doi.org/10.4149/neo_2016_606] [PMID: 27565325]
[http://dx.doi.org/10.1097/MD.0000000000016546] [PMID: 31348274]
[http://dx.doi.org/10.1080/21691401.2019.1575847] [PMID: 30873868]
[http://dx.doi.org/10.1158/0008-5472.CAN-16-2609] [PMID: 28209612]
[http://dx.doi.org/10.1100/tsw.2010.198] [PMID: 20953557]
[http://dx.doi.org/10.5966/sctm.2016-0275] [PMID: 28297576]
[http://dx.doi.org/10.1038/nature06487] [PMID: 18185580]
[http://dx.doi.org/10.1016/j.clinbiochem.2012.02.009] [PMID: 22374169]
[http://dx.doi.org/10.1016/j.yexmp.2013.12.004] [PMID: 24368110]
[http://dx.doi.org/10.1158/1541-7786.MCR-11-0272] [PMID: 22064652]
[http://dx.doi.org/10.1007/s00432-011-1068-z] [PMID: 22009180]
[http://dx.doi.org/10.1161/ATVBAHA.115.306506] [PMID: 26381870]
[http://dx.doi.org/10.1016/j.bbrc.2009.12.098] [PMID: 20034472]
[http://dx.doi.org/10.1038/onc.2013.335] [PMID: 24037526]
[http://dx.doi.org/10.1002/gcc.22181] [PMID: 24764226]
[http://dx.doi.org/10.1016/j.cllc.2016.03.012] [PMID: 27236384]
[http://dx.doi.org/10.4149/neo_2017_317] [PMID: 28253725]
[http://dx.doi.org/10.1371/journal.pone.0153046] [PMID: 27093275]
[http://dx.doi.org/10.1016/j.chest.2016.08.798]
[http://dx.doi.org/10.1371/journal.pone.0045577] [PMID: 23029111]
[http://dx.doi.org/10.1371/journal.pone.0042978] [PMID: 22900072]
[http://dx.doi.org/10.1093/abbs/gms026] [PMID: 22510476]
[http://dx.doi.org/10.1053/j.gastro.2007.05.022] [PMID: 17681183]
[http://dx.doi.org/10.1158/1078-0432.CCR-12-3302] [PMID: 23719259]
[PMID: 26309536]
[http://dx.doi.org/10.3892/ijo.2012.1707] [PMID: 23174819]
[http://dx.doi.org/10.1016/j.ccr.2010.08.013] [PMID: 20832755]
[PMID: 27226723]
[http://dx.doi.org/10.18632/oncotarget.8713] [PMID: 27081085]
[PMID: 19262443]
[http://dx.doi.org/10.1371/journal.pone.0103373] [PMID: 25098165]
[http://dx.doi.org/10.1007/s12253-015-9979-7] [PMID: 26453197]
[http://dx.doi.org/10.1007/s12032-011-9923-y] [PMID: 21516486]
[http://dx.doi.org/10.3892/or.2015.3714] [PMID: 25586265]
[http://dx.doi.org/10.1016/j.cca.2010.02.074] [PMID: 20223231]
[http://dx.doi.org/10.4161/cbt.19073] [PMID: 22237007]
[http://dx.doi.org/10.1186/1472-6890-14-9] [PMID: 24524655]
[http://dx.doi.org/10.1158/0008-5472.CAN-10-1318] [PMID: 20978187]
[http://dx.doi.org/10.1371/journal.pone.0048692] [PMID: 23144930]
[http://dx.doi.org/10.1091/mbc.e12-12-0891]
[http://dx.doi.org/10.1155/2012/595292] [PMID: 23258989]
[http://dx.doi.org/10.1371/journal.pone.0144187] [PMID: 26642205]
[http://dx.doi.org/10.1016/j.gene.2013.10.024] [PMID: 24404590]
[http://dx.doi.org/10.1177/030006051204000505] [PMID: 23206448]
[http://dx.doi.org/10.1016/j.lungcan.2018.06.027] [PMID: 30089594]
[http://dx.doi.org/10.3892/mmr.2017.6112] [PMID: 28098887]
[http://dx.doi.org/10.21037/tlcr-21-356] [PMID: 34430355]
[http://dx.doi.org/10.1158/1078-0432.CCR-13-3348] [PMID: 24833665]
[http://dx.doi.org/10.1007/s13277-015-4425-8] [PMID: 26572153]
[http://dx.doi.org/10.1038/s41388-018-0534-3] [PMID: 30390072]
[PMID: 29028091]
[http://dx.doi.org/10.1016/B978-0-12-405544-5.00003-4]
[http://dx.doi.org/10.1371/journal.pone.0055719] [PMID: 23383271]
[http://dx.doi.org/10.1007/s12094-013-1106-1] [PMID: 24019037]
[http://dx.doi.org/10.1371/journal.pone.0039011] [PMID: 22723919]
[http://dx.doi.org/10.1111/jcmm.13120] [PMID: 28266181]
[http://dx.doi.org/10.1186/s11658-017-0053-1] [PMID: 29118814]
[http://dx.doi.org/10.1016/j.biopha.2017.11.105] [PMID: 29239816]
[http://dx.doi.org/10.3892/mco.2012.18] [PMID: 24649145]
[http://dx.doi.org/10.1038/bjc.2013.623] [PMID: 24113142]
[http://dx.doi.org/10.1038/srep17031] [PMID: 26593208]
[http://dx.doi.org/10.1177/1533033820945807] [PMID: 32772818]
[http://dx.doi.org/10.1371/journal.pone.0123522] [PMID: 25856466]
[http://dx.doi.org/10.1530/EJE-20-0103] [PMID: 32698138]
[http://dx.doi.org/10.3233/CBM-170124] [PMID: 28946561]
[PMID: 26445551]
[PMID: 26884926]
[http://dx.doi.org/10.1158/1541-7786.MCR-08-0507] [PMID: 19671678]
[PMID: 30387848]
[PMID: 24696733]
[http://dx.doi.org/10.1002/jcb.26442] [PMID: 29095526]
[http://dx.doi.org/10.1016/j.biopha.2017.01.012] [PMID: 28415380]
[http://dx.doi.org/10.3727/096504016X14791726591124]
[http://dx.doi.org/10.1139/bcb-2019-0065] [PMID: 31220419]
[http://dx.doi.org/10.1016/j.ncrna.2020.01.001] [PMID: 31993547]
[http://dx.doi.org/10.1038/onc.2013.42] [PMID: 23474761]
[http://dx.doi.org/10.3389/fgene.2019.00688] [PMID: 31402930]
[http://dx.doi.org/10.1200/JCO.2009.24.9342] [PMID: 20194856]
[http://dx.doi.org/10.1186/1476-4598-13-240] [PMID: 25342548]
[http://dx.doi.org/10.1016/j.gene.2016.06.014] [PMID: 27291819]
[http://dx.doi.org/10.7150/jca.35017] [PMID: 31762811]
[http://dx.doi.org/10.1002/jcp.26543] [PMID: 29630731]
[http://dx.doi.org/10.1002/cam4.3210] [PMID: 32519472]
[http://dx.doi.org/10.3389/fgene.2019.00688] [PMID: 31402930]
[http://dx.doi.org/10.2147/OTT.S235037] [PMID: 32346298]
[http://dx.doi.org/10.3892/ol.2018.9053] [PMID: 30127957]
[http://dx.doi.org/10.1371/journal.pone.0134220] [PMID: 26237047]
[http://dx.doi.org/10.1186/1471-2164-14-139] [PMID: 23445407]
[http://dx.doi.org/10.1155/2018/5167829]
[http://dx.doi.org/10.3892/mmr.2014.2494] [PMID: 25119247]
[http://dx.doi.org/10.1186/1471-2407-14-703] [PMID: 25249344]
[PMID: 26025408]
[http://dx.doi.org/10.3892/ol.2018.8719] [PMID: 29963192]
[http://dx.doi.org/10.1007/s00109-017-1539-z] [PMID: 28487996]
[http://dx.doi.org/10.1002/ijc.26218] [PMID: 21633953]
[http://dx.doi.org/10.1002/path.2586] [PMID: 19593777]
[http://dx.doi.org/10.3233/CBM-170767] [PMID: 29103030]
[http://dx.doi.org/10.1186/s12943-017-0591-1] [PMID: 28158983]
[http://dx.doi.org/10.12659/MSM.897330] [PMID: 26918265]
[http://dx.doi.org/10.1177/1753466620915156] [PMID: 32552611]
[PMID: 32055266]
[http://dx.doi.org/10.12659/MSM.894372] [PMID: 26305739]
[http://dx.doi.org/10.1111/jcmm.14749] [PMID: 31721438]
[http://dx.doi.org/10.1080/15384101.2020.1731946] [PMID: 32106756]
[http://dx.doi.org/10.3892/or.2017.5566] [PMID: 28405690]
[http://dx.doi.org/10.1200/JCO.2008.19.4134] [PMID: 19273703]
[http://dx.doi.org/10.1016/j.bbrc.2011.07.033] [PMID: 21787752]
[http://dx.doi.org/10.1158/0008-5472.CAN-13-0297] [PMID: 23856247]
[http://dx.doi.org/10.1016/j.biopha.2017.04.086] [PMID: 28501009]
[http://dx.doi.org/10.1158/1078-0432.CCR-09-2638] [PMID: 20068099]
[http://dx.doi.org/10.18632/oncotarget.20262] [PMID: 29190887]
[http://dx.doi.org/10.12659/MSM.912581] [PMID: 30926767]
[http://dx.doi.org/10.1007/s11010-013-1755-y] [PMID: 23881177]
[http://dx.doi.org/10.3892/mmr.2021.12227]
[http://dx.doi.org/10.1111/1759-7714.14331] [PMID: 35076182]
[http://dx.doi.org/10.1007/s13402-017-0334-8] [PMID: 28634901]
[PMID: 30536324]
[http://dx.doi.org/10.1093/toxsci/kfr299] [PMID: 22048643]
[http://dx.doi.org/10.1038/emm.2015.17] [PMID: 25952770]
[http://dx.doi.org/10.1016/j.febslet.2014.05.002] [PMID: 24842609]
[PMID: 32783691]
[http://dx.doi.org/10.1186/1476-4598-13-118] [PMID: 24885288]
[http://dx.doi.org/10.18632/oncotarget.1239] [PMID: 23963114]
[http://dx.doi.org/10.1371/journal.pone.0025787] [PMID: 21984948]
[http://dx.doi.org/10.1016/j.biocel.2017.12.017] [PMID: 29275213]
[http://dx.doi.org/10.18632/oncotarget.24046] [PMID: 29552286]
[http://dx.doi.org/10.1038/ncomms11702] [PMID: 27325363]
[PMID: 26543604]
[http://dx.doi.org/10.2147/OTT.S263934] [PMID: 32801784]
[http://dx.doi.org/10.1016/j.lungcan.2015.11.013] [PMID: 26711929]
[http://dx.doi.org/10.1017/S0007114518003136] [PMID: 30375302]
[http://dx.doi.org/10.1158/1535-7163.MCT-14-0317] [PMID: 25319395]
[http://dx.doi.org/10.1111/1759-7714.12824] [PMID: 30307120]
[http://dx.doi.org/10.1007/s13277-014-3008-4] [PMID: 25725584]
[http://dx.doi.org/10.1242/jcs.118299] [PMID: 23418360]
[PMID: 31563999]
[http://dx.doi.org/10.1016/j.clinbiochem.2010.11.002] [PMID: 21093424]
[PMID: 23794259]
[http://dx.doi.org/10.1016/j.envint.2018.11.020] [PMID: 30455104]
[http://dx.doi.org/10.1002/jcb.26553] [PMID: 29231262]
[http://dx.doi.org/10.1371/journal.pone.0164207] [PMID: 27824863]
[http://dx.doi.org/10.3892/mmr.2017.6595] [PMID: 28534972]
[http://dx.doi.org/10.18632/oncotarget.3135] [PMID: 25749519]
[http://dx.doi.org/10.3892/ol.2017.6607] [PMID: 28927097]
[http://dx.doi.org/10.1002/jcb.28357] [PMID: 30656741]
[http://dx.doi.org/10.1002/jcp.26325] [PMID: 29215698]
[http://dx.doi.org/10.1002/iub.2430] [PMID: 33369006]
[http://dx.doi.org/10.1159/000485907] [PMID: 29237164]
[http://dx.doi.org/10.1007/s11596-016-1672-x] [PMID: 27924500]
[http://dx.doi.org/10.1186/s12931-020-01491-0] [PMID: 32873299]
[PMID: 31298375]
[http://dx.doi.org/10.1177/1010428317721440] [PMID: 29034803]
[PMID: 33240411]
[http://dx.doi.org/10.1186/s11658-019-0188-3] [PMID: 31832068]
[http://dx.doi.org/10.7150/thno.20112] [PMID: 29158814]
[http://dx.doi.org/10.1111/iep.12131] [PMID: 26108539]
[http://dx.doi.org/10.1186/s13578-019-0326-7] [PMID: 31406565]
[http://dx.doi.org/10.1186/s12885-019-5798-7] [PMID: 31215481]
[http://dx.doi.org/10.3892/or.2014.3519] [PMID: 25334070]
[http://dx.doi.org/10.2147/OTT.S158316] [PMID: 30022841]
[http://dx.doi.org/10.1111/jcmm.13587] [PMID: 29532994]
[PMID: 26464649]
[http://dx.doi.org/10.1093/carcin/bgr224] [PMID: 22021908]
[PMID: 26045793]
[http://dx.doi.org/10.1002/jcb.28779] [PMID: 31050363]
[http://dx.doi.org/10.2217/fon.13.242] [PMID: 24328409]
[http://dx.doi.org/10.18632/oncotarget.17648] [PMID: 28537886]
[http://dx.doi.org/10.1111/jcmm.13629] [PMID: 29664235]
[http://dx.doi.org/10.1158/0008-5472.CAN-09-4250] [PMID: 20354188]
[http://dx.doi.org/10.1158/0008-5472.CAN-07-1484] [PMID: 18006822]
[http://dx.doi.org/10.1073/pnas.0703942104] [PMID: 17911264]
[http://dx.doi.org/10.1186/1479-5876-9-6] [PMID: 21219656]
[http://dx.doi.org/10.1093/jjco/hyt084] [PMID: 23817461]
[http://dx.doi.org/10.18632/oncotarget.13022] [PMID: 27811366]
[http://dx.doi.org/10.7314/APJCP.2013.14.12.7085] [PMID: 24460255]
[http://dx.doi.org/10.2147/CMAR.S170481] [PMID: 30254489]
[http://dx.doi.org/10.1016/j.ejca.2012.09.031] [PMID: 23099007]
[http://dx.doi.org/10.1038/cdd.2009.69] [PMID: 19498445]
[http://dx.doi.org/10.1007/s11010-014-1981-y] [PMID: 24500260]
[http://dx.doi.org/10.1007/s13277-015-3075-1] [PMID: 25874488]
[http://dx.doi.org/10.1007/s13277-015-3950-9] [PMID: 26314859]
[http://dx.doi.org/10.1158/0008-5472.CAN-08-4277] [PMID: 19549910]
[http://dx.doi.org/10.1016/j.sjbs.2017.11.028] [PMID: 29551936]
[http://dx.doi.org/10.2174/1871520618666180718100656] [PMID: 30019650]
[http://dx.doi.org/10.1155/2019/2063823] [PMID: 31061821]
[http://dx.doi.org/10.3233/CBM-160667] [PMID: 27802201]
![Wayfinder Image](/images/wayfinder.jpg)