Title:Natural Flavonoid Quercetin Enhances the Anti-inflammatory
Effects of Aspirin in a Preeclampsia-like Rat Model Induced by
Lipopolysaccharide
Volume: 23
Issue: 5
Author(s): Dan Chen, Shuangyan Yang*, Jie Ding and Ailing Liu
Affiliation:
- Obstetrics Ward 1, Cangzhou Central Hospital, No.16 Xinhua West Road, Cangzhou 061000, Hebei, China
Keywords:
Preeclampsia, aspirin, quercetin, lipopolysaccharides, macrophages, pathogenesis.
Abstract:
Background: Preeclampsia is a disorder of hypertension and proteinuria
accompanied by abnormal inflammatory responses. Both aspirin and quercetin possess
anti-inflammatory and anti-hypertensive properties. A low dose of aspirin is
recommended for the prevention of preeclampsia in patients with preeclampsia history.
Whether quercetin can enhance the effect of aspirin on preeclampsia remains elusive.
Methods: Female Sprague-Dawley pregnant rats were treated with daily administration
of aspirin, quercetin, or a combination of aspirin and quercetin and subsequently
received lipopolysaccharides (LPS) injection to induce preeclampsia-like symptoms. The
systolic blood pressure and proteinuria from all groups of rats were assessed.
Results: Our results demonstrated that the combination of quercetin and aspirin exerted
significantly stronger effects than aspirin alone on decreasing systolic blood pressure
and proteinuria, reducing pro-inflammatory cytokine production, and inhibiting M1-type
decidual macrophages polarization in an LPS-induced rat model of preeclampsia.
Conclusion: This study suggested that quercetin may serve as an excellent supplement
to aspirin in preventing or treating patients with preeclampsia.
