Title:Impact of Indazole Scaffold as Antibacterial and Antifungal Agent
Volume: 22
Issue: 14
Author(s): Sitansu Sekhar Nanda*, Dong Kee Yi*, Om Prakash Panda, Sridevi Chigurupati, Tapas Kumar Mohapatra and Md. Imran Hossain
Affiliation:
- Department of Chemistry, Myongji University, Yongin, 17058, South Korea
- Department of Chemistry, Myongji University, Yongin, 17058, South Korea
Keywords:
Indazole, Antifungal, Antimicrobial, Chalcone, cox-1, cox-2.
Abstract: Heterocycles consisting of a nitrogen atom, Indazole, is a pungent, biological, heterocyclic,
bicyclic compound possessing electron-rich portions. Indazole is composed of two nitrogen atoms
put under the azoles family, further called isoindazolone. It is colorless solid nitrogen–
containing heterocyclics with atomic formula-C7H6N2 are extraordinary scaffolds, still identified as
isoindazole. Therefore, analogs of Indazole have experienced expert approaches in later times because
of its special biological properties, such as anti-microbial, anti-inflammatory, anticancer, anti-
HIV and antihypertensive actions. 1H-indazole and 2H-indazole are two toutomeric forms of Indazole.
Sometimes, indazole produces three tautomeric forms that are 1H, 2H and 3H tautomers of indazole.
1H-indazole is reliable than 2H-indazole. We should note that a series of derivatives of indazole
having 2H toutomers follow hybridization of cyclic systems and act as anti-inflammatory as
well as anti-microbial compounds. It formed Indazole itself and derivatives of Indazole in natural
products. A sequence of N-methyl-3-aryl inazoles has dominant against bacterial strains like xanthomon
as campstris, Baillus cereus, Escherichia coli, Bacillus megaterium and a fungal strain candida
albicans found by in-vitro anti-microbial study of indazole derivatives.
