Title:Toward Early Diagnosis of Colorectal Cancer: Focus on Optical Nano Biosensors
Volume: 23
Issue: 9
Author(s): Mahdieh Darroudi, Kousar Ghasemi, Majid Rezayi*Majid Khazaei*
Affiliation:
- Department
of Medical Biotechnology and Nanotechnology, School of Science, Mashhad University of Medical Science, Mashhad,
Iran
- Medical
Toxicology Research Center, Mashhad University of Medical Science, Mashhad, Iran
- Metabolic Syndrome Research
Center, Mashhad University of Medical Science, Mashhad, Iran
- Department of Physiology, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran
- Metabolic Syndrome Research
Center, Mashhad University of Medical Science, Mashhad, Iran
Keywords:
Colorectal cancer, biosensor, optical sensor, biomarkers, diagnosis, detection and screening.
Abstract:
Background: Colorectal cancer is a leading cause of death among cancers worldwide,
with the symptoms mimicking other far more common lower gastrointestinal disorders.
Objective: This challenge in separating colorectal cancer from other diseases has driven researchers
to investigate a noninvasive screening technique and effective method. The early detection of
colorectal cancer is imperative. Biomarkers play a critical role in colorectal screening tests, treatment,
clinical and prognosis management. Therefore, sensitive and rapid biomarker detection
would be helpful and demand the early diagnosis of colorectal cancer.
Methods: Recently, several investigations have been performed to design biosensors for early
detection of cancer diagnosis and profiling with strong applied ability and high sensitivity.
Results: In comparison, optical biosensors are one of the promising platforms for the costeffective
and rapid detection of biomarkers. This review will focus on the advancements and progress
of the various optical-transducing approaches for diagnosing colorectal cancer.
Conclusion: Further, the prospects and limitations of these optical biosensors in colorectal cancer
diagnosis will be discussed. Here, an overview of optical biosensors and meaningful information
for scientists worldwide will be demonstrated.