Title:Dracaenone, a Novel Type of Homoisoflavone: Natural Source, Biological Activity
and Chemical Synthesis
Volume: 26
Issue: 9
Author(s): Mei-Mei Li, Jun Lu*Yun Deng*
Affiliation:
- State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese
Medicine, Chengdu, 611137, China
- Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese
Medicine, Hong Kong Baptist University, Hong Kong SAR, 999077, China
- State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese
Medicine, Chengdu, 611137, China
Keywords:
Dracaenone, natural products, spiro-bridged scaffold, natural source, synthesis, biological activities.
Abstract: The discovery and synthesis of natural products, especially those possessing novel
scaffolds, are crucial to the development of new drugs. Dracaenones are part of homoisoflavone
natural products, owning a complex spiro-bridged polycyclic structure bearing benzylic
quaternary carbon centers, and some of them reveal considerable biological activity. There
have been continuous studies on these compounds due to the rare structure and important biological
properties. However, a systematic summary and analysis for dracaenone is lacking.
This review aims to generally summarize the natural source, synthetic strategies and biological
activities of dracaenones, moreover, the limitations, challenges, and future prospects were
discussed, wishing to provide references for the follow-up study of compounds with similar
skeleton.