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Current Protein & Peptide Science

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ISSN (Print): 1389-2037
ISSN (Online): 1875-5550

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Mini-Review Article

Gasdermins: Pore-forming Proteins as a Potential Therapeutic Target

Author(s): Kripa Jain, Kalyani Barve and Lokesh Kumar Bhatt*

Volume 23, Issue 3, 2022

Published on: 27 May, 2022

Page: [133 - 151] Pages: 19

DOI: 10.2174/1389203723666220510123740

Price: $65

Abstract

Gasdermins are novel pore forming proteins that comprise Gasdermin A, Gasdermin B, Gasdermin C, Gasdermin D, Gasdermin E and Pejvakin (DFNB59). Recently, pyroptosis has been redefined as "Gasdermin mediated necrosis", as gasdermins are key regulators of apoptosis, necrosis, and pyroptosis. The discovery of the gasdermin family has broadened the field of pyroptosis studies. Studies have correlated gasdermins with several diseases. This review summarizes the physiological roles and signal transduction of gasdermins. It further highlights the role of gasdermins in pathological conditions like autoimmune disease, kidney diseases, and central nervous system diseases.

Keywords: Gasdermins, pyroptosis, autoimmune disease, kidney diseases, CNS diseases, gasdermin mediated necrosis.

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Graphical Abstract

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