Title:Role of G-Proteins and GPCR-Mediated Signalling in Neuropathophysiology
Volume: 22
Issue: 1
Author(s): Md. Mominur Rahman, Sadia Afsana Mim, Md. Rezaul Islam, Nasrin Sultana, Muniruddin Ahmed and Mohammad Amjad Kamal*
Affiliation:
- Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka, Bangladesh
- King Fahd Medical Research Center, King Abdulaziz University, Saudi Arabia
- Institutes for Systems Genetics,
Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu
610041, Sichuan, Chinaa
- Enzymoics; Novel Global Community Educational Foundation, Australia
Keywords:
Alzheimer's disease, G protein-coupled receptors, neuropathophysiology, psychiatric receptors, neurotransmitters, neurological disorders.
Abstract: G-protein-coupled receptors (GPCRs) are activated by manifold neurotransmitters, and their
activation, in turn, evokes slow synaptic transmission. They are profoundly related to numerous psychiatric
and neurological disorders such as schizophrenia and Parkinson's disease. The significant malady
indications for GPCR modulators demonstrate a change towards obesity, diabetes, and Alzheimer's
disease, while other central nervous system disorders persist highly represented. GPR52, GPR6,
and GPR8 are recognised as orphan GPCRs, co-exist either with both the dopamine D2 and D1 receptors
in neurons of the basal ganglia or with the dopamine D2 receptor alone, and recommend that between
these orphan receptors, GPR52 has the maximum potential of being a therapeutic psychiatric
receptor. Genetically modified creature models and molecular biological investigations have suggested
that these improved GPCRs could be potential therapeutic psychiatric receptors. In this perspective,
the role of molecular targets in GPCR-mediated signalling has been discussed that would be novel
drug design and discovery options for a scientist to elaborate previous knowledge with modern techniques.
