Title:Smart Advancements for Targeting Solid Tumors via Protein and Peptide
Drug Delivery (PPD)
Volume: 20
Issue: 6
Author(s): Siddharth Singh, Priyanka Sanwal, Samir Bhargava, Ashok Behera, Shuchi Upadhyay, Md. Habban Akhter, Manish Gupta and Shraddha Manish Gupta*
Affiliation:
- Department of Pharmaceutical Sciences, School of Health Sciences and Technology, University of Petroleum and Energy
Studies (UPES), Energy Acres, Bidholi, via Premnagar, Dehradun, 248007, Uttarakhand, India
Keywords:
Solid tumors, protein, peptide drug delivery, metabolism, molecular weight, fluid pressure.
Abstract: Proteins and peptides possess considerable potential in treating solid tumors because of their
unique properties. At present, there are over 100 peptide-based formulations on the market. Today,
peptides and proteins are in more demand due to their selective nature and high target-binding efficiency.
Targeting solid tumors with compounds of molecular weight less than 10 kDa are much more desirable
because they undergo excessive penetration in view of the fact that they are small sized. The solid
tumors have thick tissues and possess excessive interstitial fluid pressure, because of which high molecular
compounds cannot enter. The properties of proteins and peptides induce low toxic effects and
lessen the major side effects caused by chemical-based drugs. However, their delivery is quite challenging
as most proteins and peptides stop functioning therapeutically when following a parenteral route of
administration. This paper elaborates on the importance of new age formulations of peptides and proteins
followed by their recently documented advancements that increase their stability and delay their
metabolism, which helps to target solid tumors.