Circulating MicroRNAs as a New Class of Biomarkers of Physiological
Reactions of the Organism to the Intake of Dietary Supplements and
Drugs

Pavel   V.   Postnikov; Yulia   A.   Efimova; Irina   V.   Pronina
doi:10.2174/2211536611666220422123437
Abstract

Background: The analysis of individual microRNAs (miRNAs) as a diagnostic and prognostic tool for the effective treatment of various diseases has aroused particular interest in the scientific community. The determination of circulating miRNAs makes it possible to assess biological changes associated with nutritional processes, the intake of dietary supplements and drugs, etc. The profile of circulating miRNAs reflects the individual adaptation of the organism to the effect of specific environmental conditions.
Objective: The objective of this study is to systematize the data and show the importance of circulating miRNAs as new potential biomarkers of the organism's response to the intake of various dietary supplements, drugs, and consider the possibility of their use in doping control.
Methods: A systematic analysis of scientific publications (ncbi.nlm.nih.gov) on the miRNA expression profile in response to the intake of dietary supplements and drugs most often used by athletes, and supposed their role as potential markers in modern doping control was carried out.
Results: The profile of circulating miRNAs is highly dependent on the intake of a particular drug, and, therefore, may be used as a marker of the effects of biologically active supplements and drugs including the substances from the Prohibited List of the World Anti-Doping Agency (WADA).
Conclusion: Monitoring of circulating miRNAs can serve as a high-precision marker for detecting doping abuse in elite sports. However, it is necessary to conduct additional studies on the effect of complex drugs on the profile of circulating miRNAs and individual circulating miRNAs on a particular biological process.
Keywords: microRNA biomarkers, biologically active supplements, medical supplies, drugs, doping, dietary supplements.
« Previous Next »
Graphical Abstract

[1] 
Weber JA, Baxter DH, Zhang S, et al. The microRNA spectrum in 12 body fluids. Clin Chem  2010; 56(11): 1733-41.
[http://dx.doi.org/10.1373/clinchem.2010.147405] [PMID:  20847327] 
[2] 
Zenz T, Mohr J, Eldering E, et al. miR-34a as part of the resistance network in chronic lymphocytic leukemia. Blood  2009; 113(16): 3801-8.
[http://dx.doi.org/10.1182/blood-2008-08-172254] [PMID:  18941118] 
[3] 
Mahesh G, Biswas R. MicroRNA-155: A master regulator of inflammation. J Interferon Cytokine Res  2019; 39(6): 321-30.
[http://dx.doi.org/10.1089/jir.2018.0155] [PMID:  30998423] 
[4] 
Kamity R, Sharma S, Hanna N. MicroRNA-mediated control of inflammation and tolerance in pregnancy. Front Immunol  2019; 10: 718.
[http://dx.doi.org/10.3389/fimmu.2019.00718] [PMID:  31024550] 
[5] 
Baggish AL, Hale A, Weiner RB, et al. Dynamic regulation of circulating microRNA during acute exhaustive exercise and sustained aerobic exercise training. J Physiol  2011; 589(16): 3983-94.
[http://dx.doi.org/10.1113/jphysiol.2011.213363] [PMID:  21690193] 
[6] 
Pfaff N, Moritz T, Thum T, Cantz T. miRNAs involved in the generation, maintenance, and differentiation of pluripotent cells. J Mol Med (Berl)  2012; 90(7): 747-52.
[http://dx.doi.org/10.1007/s00109-012-0922-z] [PMID:  22684238] 
[7] 
Cheng AM, Byrom MW, Shelton J, Ford LP. Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis. Nucleic Acids Res  2005; 33(4): 1290-7.
[http://dx.doi.org/10.1093/nar/gki200] [PMID:  15741182] 
[8] 
Zhang Y, Liu D, Chen X, et al. Secreted monocytic miR-150 enhances targeted endothelial cell migration. Mol Cell  2010; 39(1): 133-44.
[http://dx.doi.org/10.1016/j.molcel.2010.06.010] [PMID:  20603081] 
[9] 
Ponzetto F, Giraud S, Leuenberger N, et al. Methods for doping detection. Front Horm Res  2016; 47: 153-67.
[http://dx.doi.org/10.1159/000445177] [PMID:  27348309] 
[10] 
Sessa F, Salerno M, Di Mizio G, et al. Anabolic androgenic steroids: Searching new molecular biomarkers. Front Pharmacol  2018; 9: 1321.
[http://dx.doi.org/10.3389/fphar.2018.01321] [PMID:  30524281] 
[11] 
Salamin O, Jaggi L, Baume N, Robinson N, Saugy M, Leuenberger N. Circulating microRNA-122 as potential biomarker for detection of testosterone abuse. PLoS One  2016; 11(5): e0155248.
[http://dx.doi.org/10.1371/journal.pone.0155248] [PMID:  27171140] 
[12] 
Keane J, Tajouri L, Gray B. The effect of growth hormone administration on the regulation of mitochondrial apoptosis in-vivo. Int J Mol Sci  2015; 16(12): 12753-72.
[http://dx.doi.org/10.3390/ijms160612753] [PMID:  26057745] 
[13] 
Kelly BN, Haverstick DM, Lee JK, et al. Circulating microRNA as a biomarker of human growth hormone administration to patients. Drug Test Anal  2014; 6(3): 234-8.
[http://dx.doi.org/10.1002/dta.1469] [PMID:  23495241] 
[14] 
Lehtihet M, Bhuiyan H, Dalby A, Ericsson M, Ekström L. Longitudinally
monitoring of P‐III‐NP, IGF‐I, and GH‐2000 score increases
the probability of detecting two weeks’ administration of low‐dose
recombinant growth hormone compared to GH‐2000 decision limit
and GH isoform test and micro RNA markers. Drug Test Anal  2019; 11(3): 411-21.
[http://dx.doi.org/10.1002/dta.2506] [PMID:  30223291] 
[15] 
Leuenberger N, Schumacher YO, Pradervand S, Sander T, Saugy M, Pottgiesser T. Circulating microRNAs as biomarkers for detection of autologous blood transfusion. PLoS One  2013; 8(6): e66309.
[http://dx.doi.org/10.1371/journal.pone.0066309] [PMID:  23840438] 
[16] 
Leuenberger N, Jan N, Pradervand S, Robinson N, Saugy M. Circulating microRNAs as long-term biomarkers for the detection of erythro-poiesis-stimulating agent abuse. Drug Test Anal  2011; 3(11-12): 771-6.
[http://dx.doi.org/10.1002/dta.370] [PMID:  22113880] 
[17] 
Yu SL, Chen HY, Chang GC, et al. MicroRNA signature predicts survival and relapse in lung cancer. Cancer Cell  2008; 13(1): 48-57.
[http://dx.doi.org/10.1016/j.ccr.2007.12.008] [PMID:  18167339] 
[18] 
Salerno M, Cascio O, Bertozzi G, et al. Anabolic androgenic steroids and carcinogenicity focusing on Leydig cell: A literature review. Oncotarget  2018; 9(27): 19415-26.
[http://dx.doi.org/10.18632/oncotarget.24767] [PMID:  29721213] 
[19] 
Hébert SS, De Strooper B. Alterations of the microRNA network cause neurodegenerative disease. Trends Neurosci  2009; 32(4): 199-206.
[http://dx.doi.org/10.1016/j.tins.2008.12.003] [PMID:  19268374] 
[20] 
Lecellier CH, Dunoyer P, Arar K, et al. A cellular microRNA mediates antiviral defense in human cells. Science  2005; 308(5721): 557-60.
[http://dx.doi.org/10.1126/science.1108784] [PMID:  15845854] 
[21] 
Eisenberg I, Eran A, Nishino I, et al. Distinctive patterns of microRNA expression in primary muscular disorders. Proc Natl Acad Sci USA  2007; 104(43): 17016-21.
[http://dx.doi.org/10.1073/pnas.0708115104] [PMID:  17942673] 
[22] 
Vasu S, Kumano K, Darden CM, Rahman I, Lawrence MC, Naziruddin B. MicroRNA signatures as future biomarkers for diagnosis of dia-betes states. Cells  2019; 8(12): 1533.
[http://dx.doi.org/10.3390/cells8121533] [PMID:  31795194] 
[23] 
Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell  1993; 75(5): 843-54.
[http://dx.doi.org/10.1016/0092-8674(93)90529-Y] [PMID:  8252621] 
[24] 
Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T. Identification of novel genes coding for small expressed RNAs. Science  2001; 294(5543): 853-8.
[http://dx.doi.org/10.1126/science.1064921] [PMID:  11679670] 
[25] 
Reinhart BJ, Weinstein EG, Rhoades MW, Bartel B, Bartel DP. MicroRNAs in plants. Genes Dev  2002; 16(13): 1616-26.
[http://dx.doi.org/10.1101/gad.1004402] [PMID:  12101121] 
[26] 
Grundhoff A, Sullivan CS. Virus-encoded microRNAs. Virology  2011; 411(2): 325-43.
[http://dx.doi.org/10.1016/j.virol.2011.01.002] [PMID:  21277611] 
[27] 
Griffiths-Jones S, Grocock RJ, van Dongen S, Bateman A, Enright AJ. miRBase: MicroRNA sequences, targets and gene nomenclature. Nucleic Acids Res  2006; 34(90001): D140-4.
[http://dx.doi.org/10.1093/nar/gkj112] [PMID:  16381832] 
[28] 
Kim VN, Nam JW. Genomics of microRNA. Trends Genet  2006; 22(3): 165-73.
[http://dx.doi.org/10.1016/j.tig.2006.01.003] [PMID:  16446010] 
[29] 
Ghorai A, Ghosh U. miRNA gene counts in chromosomes vary widely in a species and biogenesis of miRNA largely depends on transcrip-tion or post-transcriptional processing of coding genes. Front Genet  2014; 5: 100.
[http://dx.doi.org/10.3389/fgene.2014.00100] [PMID:  24808907] 
[30] 
Lujambio A, Calin GA, Villanueva A, et al. A microRNA DNA methylation signature for human cancer metastasis. Proc Natl Acad Sci USA  2008; 105(36): 13556-61.
[http://dx.doi.org/10.1073/pnas.0803055105] [PMID:  18768788] 
[31] 
Hammond SM. An overview of microRNAs. Adv Drug Deliv Rev  2015; 87: 3-14.
[http://dx.doi.org/10.1016/j.addr.2015.05.001] [PMID:  25979468] 
[32] 
Bernstein E, Kim SY, Carmell MA, et al. Dicer is essential for mouse development. Nat Genet  2003; 35(3): 215-7.
[http://dx.doi.org/10.1038/ng1253] [PMID:  14528307] 
[33] 
Suh MR, Lee Y, Kim JY, et al. Human embryonic stem cells express a unique set of microRNAs. Dev Biol  2004; 270(2): 488-98.
[http://dx.doi.org/10.1016/j.ydbio.2004.02.019] [PMID:  15183728] 
[34] 
Murchison EP, Partridge JF, Tam OH, Cheloufi S, Hannon GJ. Characterization of dicer-deficient murine embryonic stem cells. Proc Natl Acad Sci USA  2005; 102(34): 12135-40.
[http://dx.doi.org/10.1073/pnas.0505479102] [PMID:  16099834] 
[35] 
Kura B, Parikh M, Slezak J, Pierce GN. The influence of diet on MicroRNAs that impact cardiovascular disease. Molecules  2019; 24(8): 1509.
[http://dx.doi.org/10.3390/molecules24081509] [PMID:  30999630] 
[36] 
Parikh M, Kura B, O’Hara KA, et al. Cardioprotective effects of dietary flaxseed post-infarction are associated with changes in MicroRNA expression. Biomolecules  2020; 10(9): 1297.
[http://dx.doi.org/10.3390/biom10091297] [PMID:  32911872] 
[37] 
Brisswalter J, Louis J. Vitamin supplementation benefits in master athletes. Sports Med  2014; 44(3): 311-8.
[http://dx.doi.org/10.1007/s40279-013-0126-x] [PMID:  24323888] 
[38] 
Di Luigi L. Supplements and the endocrine system in athletes. Clin Sports Med  2008; 27(1): 131-51. ix.
[http://dx.doi.org/10.1016/j.csm.2007.09.003] [PMID: 18206572] 
[39] 
Fisher JN, Terao M, Fratelli M, et al. MicroRNA networks regulated by all-trans retinoic acid and Lapatinib control the growth, survival and motility of breast cancer cells. Oncotarget  2015; 6(15): 13176-200.
[http://dx.doi.org/10.18632/oncotarget.3759] [PMID:  25961594] 
[40] 
Khan S, Wall D, Curran C, Newell J, Kerin MJ, Dwyer RM. MicroRNA-10a is reduced in breast cancer and regulated in part through retinoic acid. BMC Cancer  2015; 15(1): 345.
[http://dx.doi.org/10.1186/s12885-015-1374-y] [PMID:  25934412] 
[41] 
Warth SC, Hoefig KP, Hiekel A, et al. Induced miR‐99a expression
represses Mtor cooperatively with miR‐150 to promote regulatory
T‐cell differentiation. EMBO J  2015; 34(9): 1195-213.
[http://dx.doi.org/10.15252/embj.201489589] [PMID: 25712478] 
[42] 
Wang Z, Fan X, Zhang R, et al. Integrative analysis of mRNA and miRNA array data reveals the suppression of retinoic acid pathway in regulatory T cells of Graves’ disease. J Clin Endocrinol Metab  2014; 99(12): E2620-7.
[http://dx.doi.org/10.1210/jc.2014-1883] [PMID:  25233152] 
[43] 
Beckett EL, Yates Z, Veysey M, Duesing K, Lucock M. The role of vitamins and minerals in modulating the expression of microRNA. Nutr Res Rev  2014; 27(1): 94-106.
[http://dx.doi.org/10.1017/S0954422414000043] [PMID:  24814762] 
[44] 
Wang XS, Gong JN, Yu J, et al. MicroRNA-29a and microRNA-142-3p are regulators of myeloid differentiation and acute myeloid leuke-mia. Blood  2012; 119(21): 4992-5004.
[http://dx.doi.org/10.1182/blood-2011-10-385716] [PMID:  22493297] 
[45] 
Hung PS, Chen FC, Kuang SH, Kao SY, Lin SC, Chang KW. miR-146a induces differentiation of periodontal ligament cells. J Dent Res  2010; 89(3): 252-7.
[http://dx.doi.org/10.1177/0022034509357411] [PMID:  20110513] 
[46] 
Rimbach G, Moehring J, Huebbe P, Lodge JK. Gene-regulatory activity of α-tocopherol. Molecules  2010; 15(3): 1746-61.
[http://dx.doi.org/10.3390/molecules15031746] [PMID:  20336011] 
[47] 
Khan AA, Agarwal H, Reddy SS, et al. MicroRNA 27a is a key modulator of cholesterol biosynthesis. Mol Cell Biol  2020; 40(9): e00470-19.
[http://dx.doi.org/10.1128/MCB.00470-19] [PMID:  32071155] 
[48] 
Gwee Sian Khee S, Mohd Yusof YA, Makpol S. Expression of senescence-associated microRNAs and target genes in cellular aging and modulation by tocotrienol-rich fraction. Oxid Med Cell Longev  2014; 2014: 1-12.
[http://dx.doi.org/10.1155/2014/725929] [PMID:  25132913] 
[49] 
Fiorino S, Bacchi-Reggiani L, Sabbatani S, et al. Possible role of tocopherols in the modulation of host microRNA with potential antiviral activity in patients with hepatitis B virus-related persistent infection: A systematic review. Br J Nutr  2014; 112(11): 1751-68.
[http://dx.doi.org/10.1017/S0007114514002839] [PMID:  25325563] 
[50] 
Nabokina SM, Ramos MB, Said HM. Mechanism(S) involved in the colon-specific expression of the thiamine pyrophosphate (Tpp) trans-porter. PLoS One  2016; 11(2): e0149255.
[http://dx.doi.org/10.1371/journal.pone.0149255] [PMID:  26901654] 
[51] 
Li C. e C, Zhou Y, Yu W. Candidate genes and potential mechanisms
for chemoradiotherapy sensitivity in locally advanced rectal
cancer. Oncol Lett  2019; 17(5): 4494-504.
[http://dx.doi.org/10.3892/ol.2019.10087] [PMID:  30944639] 
[52] 
Ramamoorthy K, Anandam KY, Yasujima T, Srinivasan P, Said HM. Posttranscriptional regulation of thiamin transporter-1 expression by microRNA-200a-3p in pancreatic acinar cells. Am J Physiol Gastrointest Liver Physiol  2020; 319(3): G323-32.
[http://dx.doi.org/10.1152/ajpgi.00178.2020] [PMID:  32683950] 
[53] 
Kim S, Rhee J, Yoo HJ, et al. Bioinformatic and metabolomic analysis reveals miR-155 regulates thiamine level in breast cancer. Cancer Lett  2015; 357(2): 488-97.
[http://dx.doi.org/10.1016/j.canlet.2014.11.058] [PMID:  25484137] 
[54] 
Beckett EL, Martin C, Choi JH, et al. Folate status, folate-related genes and serum miR-21 expression: Implications for miR-21 as a bi-omarker. BBA Clin  2015; 4: 45-51.
[http://dx.doi.org/10.1016/j.bbacli.2015.06.006] [PMID:  26674922] 
[55] 
Yadav DK, Shrestha S, Lillycrop KA, et al. Vitamin B 12 supplementation influences methylation of genes associated with Type 2 diabetes and its intermediate traits. Epigenomics  2018; 10(1): 71-90.
[http://dx.doi.org/10.2217/epi-2017-0102] [PMID:  29135286] 
[56] 
Mahajan A, Sapehia D, Thakur S, Mohanraj PS, Bagga R, Kaur J. Effect of imbalance in folate and vitamin B12 in maternal/parental diet on global methylation and regulatory miRNAs. Sci Rep  2019; 9(1): 17602.
[http://dx.doi.org/10.1038/s41598-019-54070-9] [PMID:  31772242] 
[57] 
He CS, Aw Yong XH, Walsh NP, Gleeson M. Is there an optimal vitamin D status for immunity in athletes and military personnel? Exerc Immunol Rev  2016; 22: 42-64.
[PMID: 26853300] 
[58] 
Lanteri P, Lombardi G, Colombini A, Banfi G. Vitamin D in exercise: Physiologic and analytical concerns. Clin Chim Acta  2013; 415: 45-53.
[http://dx.doi.org/10.1016/j.cca.2012.09.004] [PMID:  22975529] 
[59] 
Giangreco AA, Nonn L. The sum of many small changes: MicroRNAs are specifically and potentially globally altered by vitamin D3 me-tabolites. J Steroid Biochem Mol Biol  2013; 136: 86-93.
[http://dx.doi.org/10.1016/j.jsbmb.2013.01.001] [PMID:  23333596] 
[60] 
Jorde R, Svartberg J, Joakimsen RM, Coucheron DH. Plasma profile of microRNA after supplementation with high doses of vitamin D3 for 12 months. BMC Res Notes  2012; 5(1): 245.
[http://dx.doi.org/10.1186/1756-0500-5-245] [PMID:  22594500] 
[61] 
Lombardi G, Lippi G, Banfi G. Iron requirements and iron status of athletesSports Nutrition.  NJ, USA: Wiley-Blackwell, John Wiley & Sons 2013; pp. 229-41.
[http://dx.doi.org/10.1002/9781118692318.ch19] 
[62] 
Silva B, Faustino P. An overview of molecular basis of iron metabolism regulation and the associated pathologies. Biochim Biophys Acta Mol Basis Dis  2015; 1852(7): 1347-59.
[http://dx.doi.org/10.1016/j.bbadis.2015.03.011] [PMID:  25843914] 
[63] 
Weitz SH, Gong M, Barr I, Weiss S, Guo F. Processing of microRNA primary transcripts requires heme in mammalian cells. Proc Natl Acad Sci USA  2014; 111(5): 1861-6.
[http://dx.doi.org/10.1073/pnas.1309915111] [PMID:  24449907] 
[64] 
Pogue AI, Percy ME, Cui JG, et al. Up-regulation of NF-kB-sensitive miRNA-125b and miRNA-146a in metal sulfate-stressed human as-troglial (HAG) primary cell cultures. J Inorg Biochem  2011; 105(11): 1434-7.
[http://dx.doi.org/10.1016/j.jinorgbio.2011.05.012] [PMID:  22099153] 
[65] 
Prasad AS. Discovery of human zinc deficiency: 50 years later. J Trace Elem Med Biol  2012; 26(2-3): 66-9.
[http://dx.doi.org/10.1016/j.jtemb.2012.04.004] [PMID:  22664333] 
[66] 
Ryu MS, Langkamp-Henken B, Chang SM, Shankar MN, Cousins RJ. Genomic analysis, cytokine expression, and microRNA profiling reveal biomarkers of human dietary zinc depletion and homeostasis. Proc Natl Acad Sci USA  2011; 108(52): 20970-5.
[http://dx.doi.org/10.1073/pnas.1117207108] [PMID:  22171008] 
[67] 
Huang Y, Jia Z, Xu Y, Qin M, Feng S. Selenium protects against LPS-induced MC3T3-E1 cells apoptosis through modulation of mi-croRNA-155 and PI3K/Akt signaling pathways. Genet Mol Biol  2020; 43(3): e20190153.
[http://dx.doi.org/10.1590/1678-4685-gmb-2019-0153] [PMID:  32511663] 
[68] 
Kocic H, Damiani G, Stamenkovic B, et al. Dietary compounds as potential modulators of microRNA expression in psoriasis. Ther Adv Chronic Dis  2019; 10: 2040622319864805.
[http://dx.doi.org/10.1177/2040622319864805] [PMID:  31431821] 
[69] 
Beck R, Chandi M, Kanke M, Stýblo M, Sethupathy P. Arsenic is more potent than cadmium or manganese in disrupting the INS-1 beta cell microRNA landscape. Arch Toxicol  2019; 93(11): 3099-109.
[http://dx.doi.org/10.1007/s00204-019-02574-8] [PMID:  31555879] 
[70] 
Becker N, Lockwood CM. Pre-analytical variables in miRNA analysis. Clin Biochem  2013; 46(10-11): 861-8.
[http://dx.doi.org/10.1016/j.clinbiochem.2013.02.015] [PMID:  23466658] 
[71] 
Chen J, Xu X. Diet, epigenetic, and cancer prevention. Adv Genet  2010; 71: 237-55.
[http://dx.doi.org/10.1016/B978-0-12-380864-6.00008-0] [PMID:  20933131] 
[72] 
Gollucke A, Peres R, Jr O, Ribeiro D. Polyphenols: a nutraceutical approach against diseases. Recent Pat Food Nutr Agric  2014; 5(3): 214-9.
[http://dx.doi.org/10.2174/2212798405666131129153239] [PMID:  24294942] 
[73] 
Cione E, La Torre C, Cannataro R, Caroleo MC, Plastina P, Gallelli L. Quercetin, epigallocatechin gallate, curcumin, and resveratrol: From dietary sources to human MicroRNA modulation. Molecules  2019; 25(1): 63.
[http://dx.doi.org/10.3390/molecules25010063] [PMID:  31878082] 
[74] 
Rasheed Z, Rasheed N, Al-Shaya O. Epigallocatechin-3-O-gallate modulates global microRNA expression in interleukin-1β-stimulated hu-man osteoarthritis chondrocytes: Potential role of EGCG on negative co-regulation of microRNA-140-3p and ADAMTS5. Eur J Nutr  2018; 57(3): 917-28.
[http://dx.doi.org/10.1007/s00394-016-1375-x] [PMID:  28110479] 
[75] 
Shin S, Kim K, Lee MJ, et al. Epigallocatechin gallate-mediated alteration of the MicroRNA expression profile in 5α-dihydrotestosterone-treated human dermal papilla cells. Ann Dermatol  2016; 28(3): 327-34.
[http://dx.doi.org/10.5021/ad.2016.28.3.327] [PMID:  27274631] 
[76] 
Tili E, Michaille JJ. Resveratrol, microRNAs, inflammation, and cancer. J Nucleic Acids  2011; 2011: 102431.
[http://dx.doi.org/10.4061/2011/102431] [PMID:  21845215] 
[77] 
Kumar S, Vijayan M, Bhatti JS, Reddy PH. MicroRNAs as peripheral biomarkers in aging and age-related diseases. Prog Mol Biol Transl Sci  2017; 146: 47-94.
[http://dx.doi.org/10.1016/bs.pmbts.2016.12.013] [PMID:  28253991] 
[78] 
Tili E, Michaille JJ, Adair B, et al. Resveratrol decreases the levels of miR-155 by upregulating miR-663, a microRNA targeting JunB and JunD. Carcinogenesis  2010; 31(9): 1561-6.
[http://dx.doi.org/10.1093/carcin/bgq143] [PMID:  20622002] 
[79] 
Sakai A, Suzuki H. microRNA and Pain. Adv Exp Med Biol  2015; 888: 17-39.
[http://dx.doi.org/10.1007/978-3-319-22671-2_3] [PMID:  26663177] 
[80] 
Lötsch J, Doehring A, Mogil JS, Arndt T, Geisslinger G, Ultsch A. Functional genomics of pain in analgesic drug development and therapy. Pharmacol Ther  2013; 139(1): 60-70.
[http://dx.doi.org/10.1016/j.pharmthera.2013.04.004] [PMID:  23567662] 
[81] 
World anti-doping agency prohibited list 2021. 2021. Available
from: https://www.wada-ama.org/sites/default/files/resources/files/2021list_en.pdf (Accessed September 09, 2021).
[82] 
Jeon BS, Lee S, Hwang SR, et al. Identification of urinary microRNA biomarkers for in vivo gentamicin-induced nephrotoxicity models. J Vet Sci  2020; 21(6): e81.
[http://dx.doi.org/10.4142/jvs.2020.21.e81] [PMID:  33263228] 
[83] 
Becker E, Bengs S, Aluri S, et al. Doxycycline, metronidazole and isotretinoin: Do they modify microRNA/mRNA expression profiles and function in murine T-cells? Sci Rep  2016; 6(1): 37082.
[http://dx.doi.org/10.1038/srep37082] [PMID:  27853192] 
[84] 
Takahashi K, Tatsumi N, Fukami T, Yokoi T, Nakajima M. Integrated analysis of rifampicin-induced microRNA and gene expression changes in human hepatocytes. Drug Metab Pharmacokinet  2014; 29(4): 333-40.
[http://dx.doi.org/10.2133/dmpk.DMPK-13-RG-114] [PMID:  24552687] 
[85] 
Vliegenthart ADB, Shaffer JM, Clarke JI, et al. Comprehensive microRNA profiling in acetaminophen toxicity identifies novel circulating biomarkers for human liver and kidney injury. Sci Rep  2015; 5(1): 15501.
[http://dx.doi.org/10.1038/srep15501] [PMID:  26489516] 
[86] 
Yang X, Salminen WF, Shi Q, et al. Potential of extracellular microRNAs as biomarkers of acetaminophen toxicity in children. Toxicol Appl Pharmacol  2015; 284(2): 180-7.
[http://dx.doi.org/10.1016/j.taap.2015.02.013] [PMID:  25708609] 
[87] 
Wong A, Nejad C, Gantier M, Choy KW, Doery J, Graudins A. MicroRNA from a 12-h versus 20-h acetylcysteine infusion for paracetamol overdose. Hum Exp Toxicol  2019; 38(6): 646-54.
[http://dx.doi.org/10.1177/0960327119833740] [PMID:  30838890] 
[88] 
Vliegenthart ADB, Antoine DJ, Dear JW. Target biomarker profile for the clinical management of paracetamol overdose. Br J Clin Pharmacol  2015; 80(3): 351-62.
[http://dx.doi.org/10.1111/bcp.12699] [PMID:  26076366] 
[89] 
Yu C, Zhang X, Sun X, et al. Ketoprofen and MicroRNA-124 Co-loaded poly (lactic-co-glycolic acid) microspheres inhibit progression of Adjuvant-induced arthritis in rats. Int J Pharm  2018; 552(1-2): 148-53.
[http://dx.doi.org/10.1016/j.ijpharm.2018.09.063] [PMID:  30268854] 
[90] 
Zhao M, Yao J, Meng X, et al. Polyketal nanoparticles co-loaded with miR-124 and Ketoprofen for Treatment of Rheumatoid Arthritis. J Pharm Sci  2021; 110(5): 2233-40.
[http://dx.doi.org/10.1016/j.xphs.2021.01.024] [PMID:  33516754] 
[91] 
Dong Z, Jiang H, Jian X, Zhang W. Change of miRNA expression profiles in patients with knee osteoarthritis before and after celecoxib treatment. J Clin Lab Anal  2019; 33(1): e22648.
[http://dx.doi.org/10.1002/jcla.22648] [PMID:  30105874] 
[92] 
Kim D, Nguyen QT, Lee J, et al. Anti-inflammatory roles of glucocorticoids are mediated by Foxp3+ regulatory T Cells via a miR-342-dependent mechanism. Immunity  2020; 53(3): 581-596.e5.
[http://dx.doi.org/10.1016/j.immuni.2020.07.002] [PMID:  32707034] 
[93] 
Li J, Panganiban R, Kho AT, et al. Circulating microRNAs and treatment response in childhood asthma. Am J Respir Crit Care Med  2020; 202(1): 65-72.
[http://dx.doi.org/10.1164/rccm.201907-1454OC] [PMID:  32272022] 
[94] 
Kang H, Chen H, Huang P, et al. Glucocorticoids impair bone formation of bone marrow stromal stem cells by reciprocally regulating mi-croRNA-34a-5p. Osteoporos Int  2016; 27(4): 1493-505.
[http://dx.doi.org/10.1007/s00198-015-3381-x] [PMID:  26556739] 
[95] 
 Athlete biological passport operating guidelines. Available from: https://www.wada-ama.org/sites/default/files/resources/files/guidelines_abp_v8_final.pdf (Accessed October 13, 2021).
[96] 
Lombardi G, Lanteri P, Colombini A, Lippi G, Banfi G. Stability of haematological parameters and its relevance on the athlete’s biological passport model. Sports Med  2011; 41(12): 1033-42.
[http://dx.doi.org/10.2165/11591460-000000000-00000] [PMID:  22060177] 
[97] 
Robinson N, Giraud S, Schumacher YO, Saugy M. Influence of transport and time on blood variables commonly measured for the athlete biological passport. Drug Test Anal  2016; 8(2): 199-207.
[http://dx.doi.org/10.1002/dta.1804] [PMID:  25924812] 
[98] 
Ashenden M, Sharpe K, Plowman J, et al. Stability of athlete blood passport parameters during air freight. Int J Lab Hematol  2014; 36(5): 505-13.
[http://dx.doi.org/10.1111/ijlh.12178] [PMID:  24373122] 
[99] 
Schumacher YO, Klodt F, Nonis D, et al. The impact of long-haul air travel on variables of the athlete’s biological passport. Int J Lab Hematol  2012; 34(6): 641-7.
[http://dx.doi.org/10.1111/j.1751-553X.2012.01450.x] [PMID:  22805050] 
[100] 
Lippi G, Lima-Oliveira G, Salvagno GL, et al. Influence of a light meal on routine haematological tests. Blood Transfus  2010; 8(2): 94-9.
[http://dx.doi.org/10.2450/2009.0142-09] [PMID:  20383302] 
[101] 
Leuenberger N, Baume N, Robinson N, Saugy M. Pre-analytical and analytical aspects of EDTA-plasma iron measurement. Drug Test Anal  2016; 8(10): 1077-9.
[http://dx.doi.org/10.1002/dta.1934] [PMID:  27187526] 
[102] 
Leuenberger N, Saugy M. Circulating microRNAs: the future of biomarkers in antidoping field. Adv Exp Med Biol  2015; 888: 401-8.
[http://dx.doi.org/10.1007/978-3-319-22671-2_20] [PMID:  26663194] 
[103] 
Loup B, André F, Avignon J, et al. miRNAs detection in equine plasma by quantitative polymerase chain reaction for doping control: As-sessment of blood sampling and study of eca-miR-144 as potential erythropoiesis stimulating agent biomarker. Drug Test Anal  2022; 14(5): 953-62.
[http://dx.doi.org/10.1002/dta.3047] [PMID:  33860991] 
[104] 
Marchand A, Roulland I, Semence F, Schröder K, Domergue V, Audran M. Detection of hypoxia-regulated MicroRNAs in blood as poten-tial biomarkers of HIF stabilizer molidustat. MicroRNA  2019; 8(3): 189-97.
[http://dx.doi.org/10.2174/2211536608666190117170317] [PMID:  30657053] 
[105] 
Ebert B, Jelkmann W. Intolerability of cobalt salt as erythropoietic agent. Drug Test Anal  2014; 6(3): 185-9.
[http://dx.doi.org/10.1002/dta.1528] [PMID:  24039233] 
[106] 
Pronina IV, Mochalova ES, Efimova YA, Postnikov PV. Biological functions of cobalt and its toxicology and detection in anti-doping con-trol. Fine Chemical Technologies  2021; 16(4): 318-36.
[http://dx.doi.org/10.32362/2410-6593-2021-16-4-318-336] 
[107] 
Knoop A, Planitz P, Wüst B, Thevis M. Analysis of cobalt for human sports drug testing purposes using ICP- and LC-ICP-MS. Drug Test Anal  2020; 12(11-12): 1666-72.
[http://dx.doi.org/10.1002/dta.2962] [PMID:  33142033] 
[108] 
Sobolevsky T, Ahrens B. Measurement of urinary cobalt as its complex with 2-(5-chloro-2-pyridylazo)-5-diethylaminophenol by liquid chromatography-tandem mass spectrometry for the purpose of anti-doping control. Drug Test Anal  2021; 13(6): 1145-57.
[http://dx.doi.org/10.1002/dta.3004] [PMID:  33484083] 
[109] 
Kwak J, Choi SJ, Oh W, Yang YS, Jeon HB, Jeon ES. Cobalt chloride enhances the anti-inflammatory potency of human umbilical cord blood-derived mesenchymal stem cells through the ERK-HIF-1 α -MicroRNA-146a-mediated signaling pathway. Stem Cells Int  2018; 2018: 1-12.
[http://dx.doi.org/10.1155/2018/4978763] [PMID:  30254683] 
[110] 
Jeon ES, Shin JH, Hwang SJ, Moon GJ, Bang OY, Kim HH. Cobalt chloride induces neuronal differentiation of human mesenchymal stem cells through upregulation of microRNA-124a. Biochem Biophys Res Commun  2014; 444(4): 581-7.
[http://dx.doi.org/10.1016/j.bbrc.2014.01.114] [PMID:  24491559] 
[111] 
Gasparello J, Lamberti N, Papi C, et al. Altered erythroid-related miRNA levels as a possible novel biomarker for detection of autologous blood transfusion misuse in sport. Transfusion  2019; 59(8): 2709-21.
[http://dx.doi.org/10.1111/trf.15383] [PMID:  31148196] 
[112] 
Mussack V, Wittmann G, Pfaffl MW. On the trail of blood doping- microRNA fingerprints to monitor autologous blood transfusions in vivo. Am J Hematol  2021; 96(3): 338-53.
[http://dx.doi.org/10.1002/ajh.26078] [PMID:  33326140] 
Rights & Permissions Print Cite
Article Metrics
48
1
Journal Information
For Authors
For Editors
For Reviewers
Explore Articles
Open Access
Open Access Articles
For Visitors
DOI https://dx.doi.org/10.2174/2211536611666220422123437	Print ISSN 2211-5366
Publisher Name Bentham Science Publisher	Online ISSN 2211-5374
MicroRNA

Circulating MicroRNAs as a New Class of Biomarkers of Physiological Reactions of the Organism to the Intake of Dietary Supplements and Drugs

Abstract

Graphical Abstract

Call for Papers in Thematic Issues

Revolutionizing Animal Farming: The Impact of miRNAs on Health and Productivity

Related Journals

Related Books

Related Articles
