Title:The Effect of Gut Microbe Dysbiosis on the Pathogenesis of Alzheimer's
Disease (AD) and Related Conditions
Volume: 19
Issue: 4
Author(s): Mohamed H. Nafady, Zeinab S. Sayed, Dalia A. Abdelkawy, Mostafa E. Shebl, Reem A. Elsayed, Ghulam Md Ashraf, Asma Perveen, Mohamed S. Attia and Eshak I. Bahbah*
Affiliation:
- Faculty of
Medicine, Al-Azhar University, Damietta, Egypt
- Medical Research Group of Egypt (MRGE), Cairo, Egypt
- SevoClin
Research Group, Cairo, Egypt
Keywords:
Alzheimer's disease, Amyloid-beta, lipopolysaccharides, Blood-brain barrier, Gut microbe dysbiosis, type 2 diabetes, obesity.
Abstract: It has been hypothesized that the shift in gut microbiota composition, known as gut microbe
dysbiosis, may be correlated with the onset of Alzheimer's disease (AD), which is the most
common cause of dementia characterized by a gradual deterioration in cognitive function associated
with the development of amyloid-beta (Aβ) plaques. The gut microbiota dysbiosis induces the release
of significant amounts of amyloids, lipopolysaccharides, and neurotoxins, which might play a role in
modulating signaling pathways and immune activation, leading to the production of proinflammatory
cytokines related to the pathogenesis of AD. The dysbiosis of gut microbe is associated with various
diseases such as type 2 diabetes, obesity, hypertension, and some neuropsychiatric disorders like depression,
anxiety, and stress. It is conceivable that these diseases trigger the onset of AD. Thus, modifying
the gut microbiota composition with probiotic and prebiotic supplementation can reduce depression
and anxiety symptoms, lower stress reactivity, and improve memory. This narrative review
aimed to examine the possible role of gut microbe dysbiosis in AD's pathogenesis.