Title:Recent Advances in the Synthesis of Thiazole Ring: Mini Review
Volume: 20
Issue: 3
Author(s): Inas G. Shahin, Khaled O. Mohamed, Azza T. Taher, Abdelrahman S. Mayhoub and Asmaa E. Kassab*
Affiliation:
- Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Cairo University, Cairo,
11562, Egypt
Keywords:
Thiazole, thiourea, thioamide, thiosemicarbazone, green, scaffold, anti-cancer.
Abstract: The thiazole scaffold is an essential structural foundation in a plethora of pharmaceutical
products having an extensive array of biological activities. Consequently, its synthesis has been extensively
discussed in the literature. In this mini review, we have summarized the recent advances in thiazole
synthesis, covering articles published between 2002 and 2021. We have reviewed and discussed
various recent and novel routes for synthesizing compounds containing thiazole rings from various
starting materials such as thiourea, thioamide, or thiosemicarbazone. Additionally, we have illustrated
environmentally benign methods for thiazole synthesis. We hope that this review can help other researchers
efficiently synthesize the thiazole ring.