Title:Targeting Signaling Pathway by Curcumin in Osteosarcoma
Volume: 16
Author(s): Parnia Rahnamay Farnood, Romina Danesh Pazhooh, Zatollah Asemi*Bahman Yousefi*
Affiliation:
- Research Center for Biochemistry and Nutrition
in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, I.R. Iran
- Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
- Department of Biochemistry,
Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Keywords:
Osteosarcoma, curcumin, signaling pathway, microRNA, apoptosis, tumorigenesis.
Abstract: The most prevalent primary bone malignancy among children and adolescents is osteosarcoma.
The high mortality rate of osteosarcoma is due to lung metastasis. Despite the development
of multi-agent chemotherapy and surgical resection, patients with osteosarcoma have
a high metastasis rate and poor prognosis. Thus, it is necessary to identify novel therapeutic
agents to improve the 5-year survival rate of these patients. Curcumin, a phytochemical compound
derived from Curcuma longa, has been employed in treating several types of cancers
through various mechanisms. Also, in vitro studies have demonstrated that curcumin could inhibit
cell proliferation and induce apoptosis in osteosarcoma cells. Development in identifying
signaling pathways involved in the pathogenesis of osteosarcoma has provided insight into finding
new therapeutic targets for the treatment of this cancer. Targeting MAPK/ERK, PI3k/AKT,
Wnt/β-catenin, Notch, and MircoRNA by curcumin has been evaluated to improve outcomes in
patients with osteosarcoma. Although curcumin is a potent anti-cancer compound, it has rarely
been studied in clinical settings due to its congenital properties such as hydrophobicity and poor
bioavailability. In this review, we recapitulate and describe the effect of curcumin in regulating
signaling pathways involved in osteosarcoma.