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Review Article

靶向 Hsp90-Cdc37 相互作用在几种疾病中的治疗潜力

卷 23, 期 10, 2022

发表于: 31 May, 2022

页: [1023 - 1038] 页: 16

弟呕挨: 10.2174/1389450123666220408101544

价格: $65

摘要

热休克蛋白 (Hsp) 90 是一种 ATP 依赖性伴侣蛋白，在蛋白质的折叠、成熟和稳定性中起着至关重要的作用。 Hsp90及其客户蛋白通过调节疾病相关蛋白成为各种疾病的靶点。抑制 Hsp90 的产生和活性可防止 ATP 水解，从而导致客户蛋白质的泛素化和蛋白酶体降解。然而，Hsp90抑制剂具有明显的毒副作用和不可避免的热休克反应。细胞分裂周期 37 (Cdc37) 是一种重要的 Hsp90 激酶特异性辅助伴侣，它与 Hsp90 形成复合物以调节激酶和非激酶客户的活动、细胞通讯和信号转导。 Hsp90-Cdc37 复合物通过稳定异常客户蛋白和调节细胞生长信号来维持细胞存活。 Hsp90-Cdc37蛋白-蛋白相互作用（PPI）的异常激活往往会导致癌症和神经退行性疾病等疾病的加重。与ATP竞争性Hsp90抑制剂相比，阻断Hsp90-Cdc37 PPI具有更高的选择性、更少的毒副作用，具有更好的应用前景。这篇综述详细介绍了 Hsp90-Cdc37 PPI 的生物学特性及其在几种人类疾病中的作用。此外，对抑制剂的最新研究进展进行了总结和讨论，以指导进一步的研究和临床应用。

关键词: 热休克蛋白 90，细胞分裂周期 37，蛋白质-蛋白质相互作用，疾病，抑制剂，体内平衡。

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