Title:Therapeutic Potential and Clinical Evidence of Hesperidin as Neuroprotective
Agent
Volume: 22
Issue: 1
Author(s): Shivanki Joshi, Ashwani K. Dhingra*, Bhawna Chopra, Kumar Guarve and Deepak Bhateja
Affiliation:
- Guru Gobind Singh College of Pharmacy, Yamuna Nagar-135001, Haryana, India
Keywords:
Hesperidin, neuroprotection, Alzheimer’s, Huntington’s, Parkinson’s, clinical trials.
Abstract:
Background: Neuroprotection is preserving neural function in various neurodegenerative
diseases like Alzheimer’s, Huntington’s, Parkinson’s, and multiple sclerosis. Hesperidin, a flavanone
glycoside in citrus fruits such as sweet oranges and lemons, possesses many biological effects, including
neuroprotection.
Objective: The study aims to explore the neuropharmacological mechanisms and therapeutic potential
of hesperidin in the management of neurodegenerative disorders.
Methods: It emphasizes comparative and clinical trial studies with a number of targets reviewed from
the data available on PubMed, Science Direct, Clinicaltrails.gov, and from many reputed foundations.
Results: Escalating clinical evidence has established the inhibitory effect of hesperidin in the management
of neurodegenerative disorders. Neuroprotective potential of hesperidin is characterized by
endogenous antioxidant defence functions, improvement of neural growth factors, antineuroinflammatory
activity, and apoptotic pathways.
Conclusion: The present study highlights the beneficial neuropharmacological potential of hesperidin,
including anticonvulsant, antidepressant, antioxidant, anti-inflammatory, memory, and locomotor enhancing
activities.