Title:Vitamin D, Oxidative Stress and Glycaemic Control in Subjects with Type
2 Diabetes Mellitus: Systematic Review
Volume: 18
Issue: 9
Author(s): Mariana Román-Casas, Roxana Valdés Ramos*, Beatriz E. Martínez-Carrillo, Laura S. Gaona Valle and Itzelt Pérez Malpica
Affiliation:
- Faculty of Medicine, Universidad Autónoma del Estado de México
Keywords:
Type 2 diabetes mellitus, Vitamin D, antioxidants, oxidative stress, glycaemic control, glucose metabolism.
Abstract:
Background: Diabetes mellitus (DM) is a metabolic and chronic disorder which causes
high blood glucose concentrations and dysfunctional pancreatic beta-cells characterized by
decreased insulin secretion and signalling. Scientific evidence suggests that vitamin D supplementation
may help patients with type 2 diabetes mellitus (T2DM) improve glycaemic control,
increase insulin secretion and decrease HbA1c concentrations. Additionally, this supplementation
improves antioxidant enzyme concentrations, such as superoxide dismutase (SOD), glutathione
peroxidase (GPX), catalase (CAT) and total antioxidant capacity (TAC). Finally, some studies
have reported that supplementation decreases oxidative markers such as malondialdehyde
(MDA).
Objective: The objective of this study is to review the effect of vitamin D supplementation on
glycaemic control and oxidative stress markers in patients with T2DM. Inclusion criteria involved
adult patients with T2DM, oral vitamin D supplementation with different dosages and
undefined time. Studies including children or animals and with other pathologies were excluded.
Methods: This systematic review was conducted following Reporting Items for Systematic Reviews
and Meta-Analyses framework (PRISMA) in terms of study selection, data collection, data
analysis, and result reporting. Several databases were reviewed from 2013 to 2020: Google
Scholar, REDALYC, Scielo, Scopus and PubMed, among others; word combinations and MeSH
keywords were used to find scientific evidence on vitamin D supplementation in patients with
T2DM and their relationship with oxidative stress.
Results: After making a careful selection of the studies according to its title and abstract, 120 articles
were selected for reading the full text. Consequently, 21 studies and 1 report were included
in this review, including systematic reviews and meta-analyses.
Conclusion: Supplementation with vitamin D may help decrease glucose, and glycosylated haemoglobin
and improve insulin secretion. Subjects with T2DM have higher oxidative stress concentrations
and lower antioxidants than healthy subjects; vitamin D supplementation may help
improve oxidative and antioxidant markers.
