Title:Highlighting the Potential Role of Exosomes as the Targeted Nanotherapeutic
Carrier in Metastatic Breast Cancer
Volume: 20
Issue: 4
Author(s): Alisha Khera, Hema K. Alajangi, Akhil Khajuria, Ravi P. Barnwal*, Santosh Kumar*Gurpal Singh*
Affiliation:
- Department of Biophysics, Panjab University, Chandigarh 160014, India
- National Centre for Cell Science, NCCS
Complex, S. P. Pune University Campus, Ganeshkhind, Pune, Maharashtra 411007, India
- University Institute of
Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India
Keywords:
Breast cancer, exosomes, nanovehicles, engineering strategies, tumor, treatment.
Abstract: Breast cancer, being the second most common type of cancer, is a leading cause of death in
the female population. Of all the available treatments existing for breast cancer, exosomes appear as an
important medium for the site targeted delivery of the drugs. Exosomes, unlike all the other extracellular
vesicles, play a vital role in the transport of numerous biomolecules throughout the body and can
easily be detected because of the presence of specific biomarkers. Apart from playing a wide variety of
roles in the progression of many diseases, they are also responsible for tumor progression and metastasis
in breast cancer. Exosomes and related engineering strategies are being discussed as nano-carrier for
the delivery of different drugs in the case of breast cancer. Overall, we have discussed in this review the
role of exosomes in breast cancer and the engineering strategies being devised for making them an efficient
drug delivery system.