Title:The Relationship Between FoxP3 and SOCs3 Gene Expressions and Disease Activity in Rheumatoid Arthritis
Volume: 19
Issue: 1
Author(s): Amany M. Tawfeik, Omnia A. El-dydamoni, Hend M. Maghraby, Eman Elshohat, Nora Seliem, Hanaa A. Abou elhassan, Eman A. Kassem and Haneya A. A. Anani*
Affiliation:
- Medical Microbiology and Immunology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt
- Department of Microbiology, Faculty of Medicine, Badr University in Cairo, Badr City, Egypt
Keywords:
Rheumatoid arthritis, FoxP3, regulatory T cell, SOCs3, transcription activator, markers, anti-CCp, real-time PCR.
Abstract: Background: Immune dysregulation plays an important role in the pathogenesis of
rheumatoid arthritis (RA). The CD4+CD25 high FoxP3+ subset of regulatory T cells plays an essential
role in preventing autoimmunity and maintaining immune homeostasis. Negative regulation
of JAK/STAT signaling is controlled by Suppressor of Cytokine Signaling (SOCs3) proteins. SOCs
is produced at lower levels in RA. Our aim was to evaluate the expressional dysregulation of SOCs3
and FoxP3 genes in RA patients in relation to disease activity.
Methods: We have recruited 90 patients with RA and 60 healthy controls in case control study.
Whole blood samples were collected from RA patients and healthy subjects. The measurement of
FoxP3 and SOCs3 gene expression was performed by real-time PCR (qPCR).
Results: Patients with RA had significantly decreased expression levels of FoxP3 and SOCs3 genes
in comparison with controls (P<0.001), in addition to the insignificance correlation of both genes
with disease activity in RA patients.
Conclusion: FoxP3 and SOCs3 genes showed significant defects in rheumatoid arthritis patients
with no significant difference in disease activity.
