Title:From Elusive Monomeric Metaphosphates to Oligomeric Metaphosphate Reagents:
New Avenue to Halogen-free Phosphorylation of Biomolecules
Volume: 26
Issue: 5
Author(s): Vadim D. Romanenko*
Affiliation:
- V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of Ukraine, 1-Murmanska Street,
Kyiv-94, 02660, Ukraine
Keywords:
Metaphosphates, oligometaphosphates, phosphate transfer, halogen-free phosphorylation, phosphorylating reagents, nucleoside polyphosphates.
Abstract: This perspective highlights a new environmentally benign strategy for the introduction
of phosphate functionality into organic substrates via activated cyclic oligometaphosphates.
The use of these novel phosphorylating reagents greatly simplify the synthesis of nucleoside
mono- and polyphosphates and provides a platform to access diverse phosphorylated
amino acids, peptides, sugars, and other phosphorus-containing fine chemicals. The new phosphorylation
protocol represents an advance in terms of atom-efficiency, regioselectivity, functional
tolerance and safety for the environment.