Title:A Critical Review on Recent Heterocyclics Identified for Anti-Leishmanial
Therapy
Volume: 16
Issue: 2
Author(s): Swati Rathore, Adarsh Sahu*, Ram Kishore Agrawal and Asmita Gajbhiye Patil*
Affiliation:
- Department of Pharmaceutical Sciences, Dr. Harisingh Gour Central University, Sagar, M.P. 470003, India
- Department of Pharmaceutical Sciences, Dr. Harisingh Gour Central University, Sagar, M.P. 470003, India
Keywords:
Anti-leishmanial activity, targets, pharmacophore, heterocyclic, TRND, chemotherapy.
Abstract:
Background: Leishmaniasis is a multifaceted disease that is prevalent worldwide. It is an
epidemic, tropical/subtropical disease caused by macrophage infection by compulsive leishmania
genus intracellular parasites affecting millions of people across the globe.
Methods: The demand for effective and safe molecules in the field of leishmaniasis is still an active
research area. The lack of widely effective anti-leishmanial drugs, therefore, means a critical need for the
production of modern, effective, affordable, and safe drugs for leishmaniasis care. In the recent past,
many new pharmacophores have been synthesized and evaluated for their antileishmanial activity.
Conclusion: Many important heterocycles have proved to be effective against various leishmanial
strains in terms of both safety and efficacy. In this article, we have attempted to review the different
pharmacophores discovered in the past few years with the potential anti-leishmanial property.