Title:Novel Biomarkers of microRNAs in Gastric Cancer: An Overview from
Diagnosis to Treatment
Volume: 11
Issue: 1
Author(s): Ebrahim Mirzajani, Sogand Vahidi, Seyedeh Elham Norollahi and Ali Akbar Samadani*
Affiliation:
- Guilan Road Trauma Research Center, Guilan University of Medical Sciences, Rasht, Iran
Keywords:
microRNA, gastric cancer, biomarker, diagnosis, therapeutic target, next generation sequencing (NGS).
Abstract: Gastric cancer (GC) is the fourth most frequent disease in the world and the second cause
of cancer-related death. In this way, over 80% of diagnoses are made in the middle to advanced degrees
of the disease, underscoring the requirement for innovative biomarkers that can be identified
quickly. Meaningly, biomarkers that can complement endoscopic diagnosis and be used to detect
patients with a high risk of GC are desperately needed. These biomarkers will allow for the accurate
prediction of therapy response and prognosis in GC patients, as well as the development of an optimal
treatment strategy for each individual. Conspicuously, microRNAs (miRNAs) and small noncoding
RNA regulate the expression of target mRNA, thereby modifying critical biological mechanisms.
According to the data, abnormally miRNAs expression in GC is linked to tumor growth, carcinogenesis,
aggression, and distant metastasis. Importantly, miRNA expression patterns and nextgeneration
sequencing (NGS) can also be applied to analyze different kinds of tissues and cancers.
Given the high death rates and poor prognosis of GC, and the absence of a clinical diagnostic factor
that is adequately sensitive to GC, research on novel sensitive and specific markers for GC diagnosis
is critical. In this review, we examine the latest research findings that suggest the feasibility and
clinical utility of miRNAs in GC.
