Title:Comparative Review of Effects of Pien Tze Huang and AnGong NiuHuang Pill and their Potential on Treatment of Central Nervous System Diseases
Volume: 22
Issue: 18
Author(s): Congsheng Liu, Zhiliang Chen, Sharon L.Y. Wu, Tony C.H. Chow, Rufina S.Y. Cheng, Jocy T.C. Lee and David T. Yew*
Affiliation:
- School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Hong S.A.R., China
- Hong Kong College of Technology, Hong Hong S.A.R., China
- School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Hong S.A.R.,
China
Keywords:
Composite formula, central nervous system, neuroprotection, cardioprotection, Calculus bovis, Moschus.
Abstract: The ancient composite formulae Angong Niuhuang pill and Pien Tze Huang, which were
used a few hundred years ago to treat febrile disease and inflammation, respectively, are found to
exert effects benefiting other neurological diseases and conditions. This short review introduces the
main constituents of the two formulae, looking into both the cumulative synergetic and possible individual
effects of each herb or animal apcoien. In essence, the main effects of Angong Niuhuang
pill include anti-inflammation, antioxidation, anti-cell death, anticonvulsion, antiedema, antipyretic,
antithrombotic, antimicrobial (bacteria, viruses, fungi), neuroprotective effects, and cardiovascular
protection. The main effects of Pien Tze Huang include anti-inflammation, antioxidation, anti-cell
death, antithrombotic, antimicrobial, neuroprotective effects, and cardiovascular protection. Comparing
both composites, similarities in the effects and part of the components are found, showing
some pharmacological evidence. This review casts light on research on the effects of neuroprotective
and cardiovascular protective mechanisms as well as treatment mechanisms for cerebral accidents
from the integrative medicine perspective.