Title:Main Fabrication Methods of Micellar Nanoparticles for Nanoscale Tumor
Therapy through the Self-assembly of Amphiphilic Copolymers
Volume: 2
Issue: 4
Author(s): Fan Jia, Shishuai Su, Ruirui Zhang*Yan Wu*
Affiliation:
- University of Chinese Academy of Sciences, Beijing 100049, China
- Institute of process Engineering,
Chinese Academy of Sciences, Beijing, China
- Chinese Academy of Sciences Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Chinese Academy
of Sciences Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing
100190, China
- University of Chinese Academy of Sciences, Beijing 100049, China
Keywords:
Micellar nanoparticles, amphiphilic copolymers, nanoparticle drug carriers, tumor therapy, co-delivery strategies, nano scaletumor.
Abstract: Micellar nanoparticles synthesized through the self-assembly of amphiphilic copolymers
have been widely used to encapsulate various cancer therapeutic agents for preclinical and clinical
applications. These drug delivery systems are easy to fabricate and have good biocompatibility in
general. In this article, we provide an overview of the advantages and disadvantages of micellar nanoparticles
for the fabrication of therapeutic agent-loaded nanoparticles from amphiphilic copolymers,
the examples of common polymer materials, and methods used to prepare micellar nanoparticles,
including emulsion solvent evaporation method, double emulsion method, nanoprecipitation
method, etc. By choosing an appropriate technique, different therapeutic agents with different properties
can be incorporated into nanoparticles individually or in combination. We analyzed the parameters
of various preparation methods, with particular emphasis on improvements in improved
techniques for simultaneous co-loading of hydrophilic/hydrophobic drugs and therapeutic nucleic
acids in a single nanoparticle. It will allow researchers to choose the appropriate method to design
therapeutic agent-loaded micellar nanoparticles from amphiphilic copolymers.
