Title:Natural Compounds as Integrative Therapy for Liver Protection
against Inflammatory and Carcinogenic Mechanisms: From
Induction to Molecular Biology Advancement
Volume: 23
Issue: 3
关键词:
肝炎，NAFLD, NASH, HCC，肝病保护，shoc -saiko, YHK, FOLHK，海洋生物学，Celergen Caviarlieri。
摘要: The liver is exposed to several harmful substances that bear the potential to
cause excessive liver damage ranging from hepatitis and non-alcoholic fatty liver
disease to extreme cases of liver cirrhosis and hepatocellular carcinoma. Liver ailments
have been effectively treated from very old times with Chinese medicinal herbal
formulations and later also applied by controlled trials in Japan. However, these
traditional practices have been hardly well characterized in the past till in the last
decades when more qualified studies have been carried out. Modern advances have
given rise to specific molecular targets which are specifically good candidates for
affecting the intricate mechanisms that play a role at the molecular level. These
therapeutic regimens that mainly affect the progression of the disease by inhibiting the
gene expression levels or by blocking essential molecular pathways or releasing
cytokines may prove to play a vital role in minimizing the tissue damage. This review,
therefore, tries to throw light upon the variation in the therapies for the treatment of
benign and malignant liver disease from ancient times to the current date. Nonetheless,
clinical research exploring the effectiveness of herbal medicines in the treatment of
benign chronic liver diseases as well as prevention and treatment of HCC is still
warranted.
