Title:Bacterial Metalo-Aminopeptidases as Targets in Human Infectious
Diseases
Volume: 23
Issue: 12
关键词:
抗菌剂、二价金属阳离子、酶抑制剂复合物、金属氨基肽酶、致病菌、蛋白酶抑制剂。
摘要:
Background: Human infectious diseases caused by bacteria are a worldwide health problem
due to the increased resistance of these microorganisms to conventional antibiotics. For this
reason, the identification of novel molecular targets and the discovery of new antibacterial compounds
are urgently required. Metalo-aminopeptidases are promising targets in bacterial infections.
They participate in crucial processes for bacterial growth and pathogenesis, such as protein and peptide
degradation to supply amino acids, protein processing, access to host tissues, cysteine supply
for redox control, transcriptional regulation, site-specific DNA recombination, and hydrogen sulfide
production. Although several of these enzymes are not essential, they are required for virulence and
maximal growth in conditions of nutrient limitation and high temperatures.
Objective: In this review, we describe the structural, functional, and kinetic properties of some examples
of bacterial metalo-aminopeptidases, in the context of their use as antibacterial targets. In
addition, we present some inhibitors reported for these enzymes.
Conclusion: It is necessary to conduct a meticulous work to validate these peptidases as good/bad
targets and to identify inhibitors with potential therapeutic use.
