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Current Topics in Medicinal Chemistry

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ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

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Review Article

Discussion on the Structural Modification and Anti-tumor Activity of Flavonoids

Author(s): Zhu-Gui Zhou, Dong-Dong Li, Ying Chen, Xi Chen and Ruo-Jun Man*

Volume 22, Issue 7, 2022

Published on: 25 April, 2022

Page: [561 - 577] Pages: 17

DOI: 10.2174/1568026622666220308162049

Price: $65

Open Access Journals Promotions 2
Abstract

Flavonoids are secondary metabolites of plants. In general，most flavonoids are combined with glucosides and have extremely complex molecular structures. In nature, these flavonoids have a variety of biological activities, such as anti-oxidation，anti-virus, anti-tumor, scavenging free radicals, etc.; however，due to poor solubility and stability of flavonoids，their bioavailability is limited. The drug design method is used to modify the structure of flavonoids to give them special properties. At present, flavonoids have shown broad application prospects in treating tumors, inhibiting proliferation, migration, invasion, angiogenesis, and multi-drug resistance of tumors and have become a research hotspot.

Keywords: Flavonoids, Structural modification, Drug design, Anti-tumor activity, Mechanisms, Apoptosis.

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