Title:Medicinal Plants in Cancer Treatment: Contribution of Nuclear Factor-
Kappa B (NF-kB) Inhibitors
Volume: 22
Issue: 15
Author(s): Rina Das*, Dinesh Kumar Mehta and Meenakshi Dhanawat
Affiliation:
- M.M.College of Pharmacy, Maharishi Markandeshwar (Deemed to be) University, Mullana, Ambala, HR, India
Keywords:
Nuclear factor-kappa B (NF-κB), NF-κB inhibitors, NF-κB signalling, NF-κB signalling pathways, natural products, cancer.
Abstract: Nuclear factor-kappa B (NF-κB) is one of the principal inducible proteins and a predominant
transcription factor that is known to control gene expression in mammals. It plays a pivotal role
in regulating cell signalling in the body under certain physiological and pathological conditions. In
cancer cells, such as colon, breast, pancreatic, ovarian, melanoma, and lymphoma, the NF-κB pathway
is active. In cellular proliferation, promoting angiogenesis, invasion, metastasis of tumour cells,
and blocking apoptosis, the constitutive activity of NF-κB signalling has been reported. Therefore,
immense attention has been given to developing drugs targeting NF-κB signalling pathways to treat
many types of tumours. They are a desirable therapeutic target for drugs, and many studies have concentrated
on recognizing compounds. They may be able to reverse or standstill the growth and spread
of tumours that selectively interfere with this pathway. Recently, numerous substances derived from
plants have been evaluated as possible inhibitors of the NF-κB pathway. These include various compounds,
such as flavonoids, lignans, diterpenes, sesquiterpenes, polyphenols, etc. A study supported
by folk medicine demonstrated that plant-derived compounds could suppress NF-κB signalling. Considering
this, the present review revealed the anticancer potential of naturally occurring compounds
that inhibit the NF-κB signalling and suppress the growth and spread of cancer.
