Title:The Antibacterial Activity of Quinazoline and Quinazolinone Hybrids
Volume: 22
Issue: 12
Author(s): Zhenghua Li, Li Zhao, Yunqiang Bian, Yu Li, Jie Qu and Feng Song*
Affiliation:
- Shandong Key Laboratory of Biophysics, Institute of Biophysics, Dezhou University, Dezhou, 253023, Shandong, China
Keywords:
Quinazoline, Quinazolinone, Hybrids, Antibacterial, Drug resistance, Structure-activity relationship.
Abstract: Bacterial infections cause substantial morbidity and mortality across the world and pose
serious threats to humankind. Drug resistance, especially multidrug resistance resulting from different
defensive mechanisms in bacteria, is the leading cause of the failure of chemotherapy, making it
an urgent need to develop more effective antibacterials. Quinazoline and quinazolinone frameworks
have received considerable attention due to their diversified therapeutic potential. In particular,
quinazoline/quinazolinone hybrids can exert antibacterial activity through various mechanisms and
are useful scaffolds for the discovery of novel antibacterials. This review principally emphasizes the
antibacterial potential, structure-activity relationships (SARs), and mechanism of action of quinazoline
and quinazolinone hybrids, covering articles published between 2017 and 2021.