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Current Topics in Medicinal Chemistry

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ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

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Review Article

The Antibacterial Activity of Quinazoline and Quinazolinone Hybrids

Author(s): Zhenghua Li, Li Zhao, Yunqiang Bian, Yu Li, Jie Qu and Feng Song*

Volume 22, Issue 12, 2022

Published on: 11 April, 2022

Page: [1035 - 1044] Pages: 10

DOI: 10.2174/1568026622666220307144015

Price: $65

Abstract

Bacterial infections cause substantial morbidity and mortality across the world and pose serious threats to humankind. Drug resistance, especially multidrug resistance resulting from different defensive mechanisms in bacteria, is the leading cause of the failure of chemotherapy, making it an urgent need to develop more effective antibacterials. Quinazoline and quinazolinone frameworks have received considerable attention due to their diversified therapeutic potential. In particular, quinazoline/quinazolinone hybrids can exert antibacterial activity through various mechanisms and are useful scaffolds for the discovery of novel antibacterials. This review principally emphasizes the antibacterial potential, structure-activity relationships (SARs), and mechanism of action of quinazoline and quinazolinone hybrids, covering articles published between 2017 and 2021.

Keywords: Quinazoline, Quinazolinone, Hybrids, Antibacterial, Drug resistance, Structure-activity relationship.

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