Title:The Intrinsically Disordered Protein: A Literature Landscape
Volume: 2
Issue: 3
Author(s): Mouna Choura*, Faiçal Brini and Ahmed Rebaï
Affiliation:
- Laboratory of Plant Protection and Improvement, Center of Biotechnology of Sfax, University of Sfax, Route Sidi
Mansour, PO Box 1177, 3018 Sfax, Tunisia
Keywords:
Bibliometric, bibliography, intrinsically disordered proteins, organisations, 3D structures, drug development, proteins.
Abstract:
Background: Intrinsically disordered proteins (IDPs) are proteins that lack a predetermined
3D structure and play key cellular functions. IDPs are often involved in diseases and have
been shown to be attractive targets for drug development. The IDPs have been intensively
investigated, revealing important results.
Objective: This study aimed to evaluate the latest research bibliography since 2010, including the
latest findings, major contributors, institutions, and journals.
Methods: The bibliographic data were retrieved from PubMed from 2010 to 2020. The data
collected were then analysed by VOSviewer software (version 1.6.11).
Results: In this study, 4590 publications were retrieved for analysis. They have been published in
579 journals. Over 9683 organisations have contributed to IDP publications, with United States of
America and Russia being in the first place. Human proteins are most studied for their IDP features
and mainly in the context of diseases and drug design.
Conclusion: This bibliometric study reveals that the trend of publications is increasing year by year.
USA and Russia have contributed the most to the IDP research field. Moreover, it suggests that IDP
research remains a challenging issue that is still open for original contributions and original applications.
