Title:Curcumin as a Natural Modulator of B Lymphocytes: Evidence from In Vitro and In Vivo Studies
Volume: 22
Issue: 18
Author(s): Asadollah Mohammadi, Kazem Mashayekhi, Jamshid Gholizadeh Navashenaq and Saeed Mohammadian Haftcheshmeh*
Affiliation:
- Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran
- Healthy Ageing Research Centre, Neyshabur University of Medical Sciences, Neyshabur, Iran
Keywords:
B cells, B cell lymphoma, curcumin, inflammatory diseases, immune cells, pharmacological activities.
Abstract: B cells are the only player of humoral immune responses by the production of various types
of antibodies. However, B cells are also involved in the pathogenesis of several immune-mediated
diseases. Moreover, different types of B cell lymphoma have also been characterized. Selective depletion
of B cells by anti-CD20 and other B cell-depleting agents in the clinic can improve a wide range
of immune-mediated diseases. B cells' capacity to act as cytokine-producing cells explains how they
can control immune cells' activity and contribute to disease pathogenesis. Thus, researchers investigated
a safe, low-cost, and effective treatment modality for targeting B cells. In this respect, curcumin,
the biologically active ingredient of turmeric, has a wide range of pharmacological activities. Evidence
showed that curcumin could affect various immune cells, such as monocytes and macrophages,
dendritic cells, and T lymphocytes. However, there are few pieces of evidence about the effects of
curcumin on B cells. This study aims to review the available evidence about curcumin's modulatory
effects on B cells' proliferation, differentiation, and function in different states. Apart from normal B
cells, the modulatory effects of curcumin on B cell lymphoma will also be discussed.
