Title:Valproate Induced Acute Pancreatitis - A Unique Case Report
Volume: 17
Issue: 4
Author(s): Vikramaditya Chauhan, Munish Sharma, Ajita Kapur*Gulshan Kumar Garg
Affiliation:
- Department of Pharmacology,
Vallabhbhai Patel Chest Institute, Delhi, India
Keywords:
Valproate, acute pancreatitis, drug induced, laparotomy, case report, seizure.
Abstract:
Background: Valproate is a widely prescribed medication for the control of seizures in
the pediatric population. It has been reported to be an important implication for drug induced pancreatitis.
A case of valproate induced acute pancreatitis operated as surgical abdomen has been reported
here.
Case Report: A 13-year-old child presented to the emergency department with severe pain and abdominal
distension associated with vomiting and constipation for four days. The patient’s caregivers
did not disclose any medication history. Based on clinical examination and ultrasonography
that revealed mild free fluid, a provisional diagnosis of pyoperitoneum with peritonitis was made.
An emergency exploratory laparotomy was undertaken during which acute pancreatitis was diagnosed
intra-operatively. On further enquiry, the caregiver revealed the history of valproate intake
for the last six months for generalized tonic-clonic seizures. Valproate was discontinued and there
was complete resolution of symptoms.
Conclusion: Both clinicians, as well as caregivers of paediatric patients receiving valproate, should
be watchful regarding this possible life-threatening complication to avoid delay in diagnosis and
appropriate management.
