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Current Organic Chemistry

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ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

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Commentary

Cocaine: From a Controlled Drug by the DEA to an Approved Drug by the FDA

Author(s): Carlos E. Puerto Galvis and Vladimir V. Kouznetsov*

Volume 26, Issue 9, 2022

Published on: 31 May, 2022

Page: [817 - 821] Pages: 5

DOI: 10.2174/1385272826666220221102840

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Abstract

NumbrinoTM, a nasal anesthetic solution based on cocaine hydrochloride, has recently been approved by the FDA for diagnostic procedures and surgery – now, what will be the role of the controlling agencies and the legislation of producing countries to face the imminent medicinal use of cocaine? Would chemistry be the protagonist in proposing alternative approaches to help and overcome this issue? The debate is open with this commentary.

Keywords: Cocaine, NumbrinoTM, anesthetics, tropane derivatives, drug legislation, drug.

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[1]
Karch, S.B. Cocaine: History, use, abuse. J. R. Soc. Med., 1999, 92(8), 393-397.
[http://dx.doi.org/10.1177/014107689909200803 ] [PMID: 10656003]
[2]
Grinspoon, L.; Bakalar, J.B. Coca and cocaine as medicines: An historical review. J. Ethnopharmacol., 1981, 3(2-3), 149-159.
[http://dx.doi.org/10.1016/0378-8741(81)90051-9 ] [PMID: 7017287]
[3]
Altman, A.J.; Albert, D.M.; Fournier, G.A. Cocaine’s use in ophthalmology: Our 100-year heritage. Surv. Ophthalmol., 1985, 29(4), 300-306.
[http://dx.doi.org/10.1016/0039-6257(85)90154-7 ] [PMID: 3885453]
[4]
Goerig, M.; Bacon, D.; van Zundert, A. Carl Koller, cocaine, and local anesthesia: Some less known and forgotten facts. Reg. Anesth. Pain Med., 2012, 37(3), 318-324.
[http://dx.doi.org/10.1097/AAP.0b013e31825051f3 ] [PMID: 22531385]
[5]
Gootenberg, P.; Zheng, F.; Zhan, C-G. Andean Cocaine: The Making of a Global Drug; University of North Carolina Press: USA, 2008, pp. 35-90.
[6]
Dolgin, E. What legal weed in Canada means for science. Nature, 2018, 562(7727), 327-330.
[http://dx.doi.org/10.1038/d41586-018-07037-1 ] [PMID: 30333597]
[7]
Owens, B. The professionalization of cannabis growing. Nature, 2019, 572(7771), S10-S11.
[http://dx.doi.org/10.1038/d41586-019-02527-2 ] [PMID: 31462785]
[8]
Zheng, F.; Zhan, C-G. The Neuroscience of Cocaine: Mechanisms and Treatment; Preedy, V.R., Ed.; Academic Press: USA, 2017, pp. 663-672.
[http://dx.doi.org/10.1016/B978-0-12-803750-8.00067-1]
[9]
Ritz, M.C.; Lamb, R.J.; Goldberg, S.R.; Kuhar, M.J. Cocaine receptors on dopamine transporters are related to self-administration of cocaine. Science, 1987, 237(4819), 1219-1223.
[http://dx.doi.org/10.1126/science.2820058 ] [PMID: 2820058]
[10]
Volkow, N.D.; Tomasi, D.; Wang, G-J.; Logan, J.; Alexoff, D.L.; Jayne, M.; Fowler, J.S.; Wong, C.; Yin, P.; Du, C. Stimulant-induced dopamine increases are markedly blunted in active cocaine abusers. Mol. Psychiatry, 2014, 19(9), 1037-1043.
[http://dx.doi.org/10.1038/mp.2014.58 ] [PMID: 24912491]
[11]
Delint-Ramirez, I.; Garcia-Oscos, F.; Segev, A.; Kourrich, S. Cocaine engages a non-canonical, do-pamine-independent, mechanism that controls neuronal excitability in the nucleus accumbens. Mol. Psychiatry, 2020, 25(3), 680-691.
[http://dx.doi.org/10.1038/s41380-018-0092-7 ] [PMID: 29880884]
[12]
Redish, A.D. Addiction as a computational process gone awry. Science, 2004, 306(5703), 1944-1947.
[http://dx.doi.org/10.1126/science.1102384 ] [PMID: 15591205]
[13]
Pierce, R.C.; Fant, B.; Swinford-Jackson, S.E.; Heller, E.A.; Berrettini, W.H.; Wimmer, M.E. Envi-ronmental, genetic and epigenetic contributions to cocaine addiction. Neuropsychopharmacology, 2018, 43(7), 1471-1480.
[http://dx.doi.org/10.1038/s41386-018-0008-x ] [PMID: 29453446]
[14]
Zheng, F.; Zhan, C-G. Are pharmacokinetic approaches feasible for treatment of cocaine addiction and overdose? Future Med. Chem., 2012, 4(2), 125-128.
[http://dx.doi.org/10.4155/fmc.11.171 ] [PMID: 22300091]
[15]
World Drug Report 2019. United Nations Office on Drugs and Crime. Available from: https://wdr.unodc.org/wdr2019/
[16]
Richards, J.R.; Laurin, E.G. Cocaine. Available from: https://www.ncbi.nlm.nih.gov/books/NBK430769/
[17]
Ruetsch, Y.A.; Böni, T.; Borgeat, A. From cocaine to ropivacaine: The history of local anesthetic drugs. Curr. Top. Med. Chem., 2001, 1(3), 175-182.
[http://dx.doi.org/10.2174/1568026013395335 ] [PMID: 11895133]
[18]
Horton, A. How to Fix a Drug Scandal: Behind a staggering Netflix crime docuseries. The Guardian. Available from: https://www.theguardian.com/tv-and-radio/2020/apr/01/how-to-fix-a-drug-scandal-netflix-erin-lee-carr
[19]
Grynkiewicz, G.; Gadzikowska, M. Tropane alkaloids as medicinally useful natural products and their synthetic derivatives as new drugs. Pharmacol. Rep., 2008, 60(4), 439-463.
[PMID: 18799813]
[20]
Stehouwer, J.S.; Daniel, L.M.; Chen, P.; Voll, R.J.; Williams, L.; Plott, S.J.; Votaw, J.R.; Owens, M.J.; Howell, L.; Goodman, M.M. Synthesis, fluorine-18 radiolabeling, and biological evaluation of N-((E)-4-fluorobut-2-en-1-yl)-2β-carbomethoxy-3β-(4′-halophenyl)nortropanes: candidate radiolig-ands for in vivo imaging of the brain dopamine transporter with positron emission tomography. J. Med. Chem., 2010, 53(15), 5549-5557.
[http://dx.doi.org/10.1021/jm100269c ] [PMID: 20597489]
[21]
Qiao, H.; Zhu, L.; Lieberman, B.P.; Zha, Z.; Plössl, K.; Kung, H.F. Synthesis and evaluation of novel tropane derivatives as potential PET imaging agents for the dopamine transporter. Bioorg. Med. Chem. Lett., 2012, 22(13), 4303-4306.
[http://dx.doi.org/10.1016/j.bmcl.2012.05.030 ] [PMID: 22658558]
[22]
Goodman, M.M.; Shi, B.Z.; Keil, R.N. Labeled cocaine analogs. U.S. Patent No. 5, 864,038, 1999.
[23]
Zheng, X.; Chen, X.; Zhang, T.; Zhan, M.; Zhan, C-G.; Zheng, F. Catalytic activities of cocaine hy-drolases against the most toxic cocaine metabolite norcocaethylene. Org. Biomol. Chem., 2020, 18(10), 1968-1977.
[http://dx.doi.org/10.1039/C9OB02762A ] [PMID: 32101217]
[24]
FDA. Full prescribing information for NumbrinoTM Available from:https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/209575s000lbl.pdf
[25]
The guardian. Cocaine production in Colombia is at historic highs. The Economist. Available from: https://www.theguardian.com/tv-and-radio/2020/apr/01/how-to-fix-a-drug-scandal-netflix-erin-lee-carr
[26]
Gao, D.; Cho, H.; Yang, W.; Pan, Y.; Yang, G.; Tai, H-H.; Zhan, C-G. Computational design of a human butyrylcholinesterase mutant for accelerating cocaine hydrolysis based on the transition-state simulation. Angew. Chem. Int. Ed., 2006, 45(4), 653-657.
[http://dx.doi.org/10.1002/anie.200503025 ] [PMID: 16355430]
[27]
Zhou, S.; Huang, G.; Chen, G. Synthesis and biological activities of local anesthetics. RSC Advances, 2019, 9(70), 41173-41191.
[http://dx.doi.org/10.1039/C9RA09287K]
[28]
Wight, A.J. Colombia creates its first science ministry. Nature, 2019, 565(7739), 273-274.
[http://dx.doi.org/10.1038/d41586-019-00087-z ] [PMID: 30647420]
[29]
Palmer, J. Coca leaves first chewed 8,000 years ago. BBC News. Available from: https://www.bbc.com/news/science-environment-11878241

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