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Review Article

The Role of (Pro)Renin Receptor in the Metabolic Syndrome

Author(s): Kellea Nichols and Frederique Yiannikouris*

Volume 18, Issue 2, 2022

Published on: 27 May, 2022

Page: [117 - 124] Pages: 8

DOI: 10.2174/1573402118666220216104816

Price: $65

Open Access Journals Promotions 2
Abstract

The prorenin receptor (PRR) is a complex multi-functional single transmembrane protein receptor that is ubiquitously expressed in organs and tissues throughout the body. PRR is involved in different cellular mechanisms that comprise the generation of Angiotensin II, the activation of Wnt/β-catenin signaling, the stimulation of ERK 1/2 pathway, and the proper functioning of the vacuolar H+-ATPase. Evidence supports the role of PRR and its soluble form, sPRR, in the classical features of the metabolic syndrome, including obesity, hypertension, diabetes, and disruption of lipid homeostasis. This review summarizes our current knowledge and highlights new advances in the pathophysiological function of PRR and sPRR in adipogenesis, adipocyte differentiation, lipolysis, glucose and insulin resistance, lipid homeostasis, energy metabolism, and blood pressure regulation.

Keywords: (Pro)renin receptor, metabolism, blood pressure, Wnt/β-catenin signaling, lipolysis, single transmembrane protein receptor, hypertension, metabolic syndrome.

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[1]
Ogden CL, Carroll MD, Kit BK, Flegal KM. Prevalence of obesity in the United States, 2009-2010. NCHS Data Brief 2012; (82): 1-8.
[PMID: 22617494]
[2]
Ardern CI, Janssen I. Metabolic syndrome and its association with morbidity and mortality. Appl Physiol Nutr Metab 2007; 32(1): 33-45.
[http://dx.doi.org/10.1139/h06-099] [PMID: 17332783]
[3]
Nguyen G, Delarue F, Burcklé C, Bouzhir L, Giller T, Sraer JD. Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin. J Clin Invest 2002; 109(11): 1417-27.
[http://dx.doi.org/10.1172/JCI0214276] [PMID: 12045255]
[4]
Wolny A, Clozel JP, Rein J, et al. Functional and biochemical analysis of angiotensin II-forming pathways in the human heart. Circ Res 1997; 80(2): 219-27.
[http://dx.doi.org/10.1161/01.RES.80.2.219] [PMID: 9012744]
[5]
Nabi AH, Kageshima A, Uddin MN, Nakagawa T, Park EY, Suzuki F. Binding properties of rat prorenin and renin to the recombinant rat renin/prorenin receptor prepared by a baculovirus expression system. Int J Mol Med 2006; 18(3): 483-8.
[http://dx.doi.org/10.3892/ijmm.18.3.483] [PMID: 16865234]
[6]
Batenburg WW, Danser AH. (Pro)renin and its receptors: pathophysiological implications. Clin Sci (Lond) 2012; 123(3): 121-33.
[http://dx.doi.org/10.1042/CS20120042] [PMID: 22494159]
[7]
Achard V, Boullu-Ciocca S, Desbriere R, Nguyen G, Grino M. Renin receptor expression in human adipose tissue. Am J Physiol Regul Integr Comp Physiol 2007; 292(1): R274-82.
[http://dx.doi.org/10.1152/ajpregu.00439.2005] [PMID: 17197644]
[8]
Achard V, Tassistro V, Boullu-Ciocca S, Grino M. Expression and nutritional regulation of the (pro)renin receptor in rat visceral adipose tissue. J Endocrinol Invest 2011; 34(11): 840-6.
[PMID: 21483231]
[9]
Müller DN, Binger KJ, Riediger F. Prorenin receptor regulates more than the renin-angiotensin system. Ann Med 2012; 44 (Suppl. 1): S43-8.
[http://dx.doi.org/10.3109/07853890.2012.660496] [PMID: 22713148]
[10]
Wu CH, Mohammadmoradi S, Thompson J, et al. Adipocyte (Pro)renin-receptor deficiency induces lipodystrophy, liver steatosis and increases blood pressure in male mice. Hypertension 2016; 68(1): 213-9.
[http://dx.doi.org/10.1161/HYPERTENSIONAHA.115.06954] [PMID: 27185751]
[11]
Yiannikouris F, Gupte M, Putnam K, et al. Adipocyte deficiency of angiotensinogen prevents obesity-induced hypertension in male mice. Hypertension 2012; 60(6): 1524-30.
[http://dx.doi.org/10.1161/HYPERTENSIONAHA.112.192690] [PMID: 23108647]
[12]
Burcklé C, Bader M. Prorenin and its ancient receptor. Hypertension 2006; 48(4): 549-51.
[http://dx.doi.org/10.1161/01.HYP.0000241132.48495.df] [PMID: 16940209]
[13]
Shan Z, Cuadra AE, Sumners C, Raizada MK. Characterization of a functional (pro)renin receptor in rat brain neurons. Exp Physiol 2008; 93(5): 701-8.
[http://dx.doi.org/10.1113/expphysiol.2008.041988] [PMID: 18326551]
[14]
Alcazar O, Cousins SW, Striker GE, Marin-Castano ME. (Pro)renin receptor is expressed in human retinal pigment epithelium and participates in extracellular matrix remodeling. Exp Eye Res 2009; 89(5): 638-47.
[http://dx.doi.org/10.1016/j.exer.2009.06.014] [PMID: 19580809]
[15]
Feldman DL, Jin L, Xuan H, et al. Effects of aliskiren on blood pressure, albuminuria, and (pro)renin receptor expression in diabetic TG(mRen-2)27 rats. Hypertension 2008; 52(1): 130-6.
[http://dx.doi.org/10.1161/HYPERTENSIONAHA.107.108845] [PMID: 18490518]
[16]
Gálvez-Prieto B, Bolbrinker J, Stucchi P, et al. Comparative expression analysis of the renin-angiotensin system components between white and brown perivascular adipose tissue. J Endocrinol 2008; 197(1): 55-64.
[http://dx.doi.org/10.1677/JOE-07-0284] [PMID: 18372232]
[17]
Zorad S, Dou JT, Benicky J, et al. Long-term angiotensin II AT1 receptor inhibition produces adipose tissue hypotrophy accompanied by increased expression of adiponectin and PPARgamma. Eur J Pharmacol 2006; 552(1-3): 112-22.
[http://dx.doi.org/10.1016/j.ejphar.2006.08.062] [PMID: 17064684]
[18]
Tan P, Blais C, Nguyen TM, Schiller PW, Gutkowska J, Lavoie JL. Prorenin/renin receptor blockade promotes a healthy fat distribution in obese mice. Obesity (Silver Spring) 2016; 24(9): 1946-54.
[http://dx.doi.org/10.1002/oby.21592] [PMID: 27458124]
[19]
Gonzalez AA, Lara LS, Luffman C, Seth DM, Prieto MC. Soluble form of the (pro)renin receptor is augmented in the collecting duct and urine of chronic angiotensin II-dependent hypertensive rats. Hypertension 2011; 57(4): 859-64.
[http://dx.doi.org/10.1161/HYPERTENSIONAHA.110.167957] [PMID: 21321306]
[20]
Shamansurova Z, Tan P, Ahmed B, Pepin E, Seda O, Lavoie JL. Adipose tissue (P)RR regulates insulin sensitivity, fat mass and body weight. Mol Metab 2016; 5(10): 959-69.
[http://dx.doi.org/10.1016/j.molmet.2016.08.009] [PMID: 27689008]
[21]
Tan P, Shamansurova Z, Bisotto S, et al. Impact of the prorenin/renin receptor on the development of obesity and associated cardiometabolic risk factors. Obesity (Silver Spring) 2014; 22(10): 2201-9.
[http://dx.doi.org/10.1002/oby.20844] [PMID: 25044950]
[22]
Lu X, Wang F, Xu C, et al. Soluble (pro)renin receptor via β-catenin enhances urine concentration capability as a target of liver X receptor. Proc Natl Acad Sci USA 2016; 113(13): E1898-906.
[http://dx.doi.org/10.1073/pnas.1602397113] [PMID: 26984496]
[23]
Cassis LA, Police SB, Yiannikouris F, Thatcher SE. Local adipose tissue renin-angiotensin system. Curr Hypertens Rep 2008; 10(2): 93-8.
[http://dx.doi.org/10.1007/s11906-008-0019-9] [PMID: 18474174]
[24]
Nguyen G. The (pro)renin receptor: pathophysiological roles in cardiovascular and renal pathology. Curr Opin Nephrol Hypertens 2007; 16(2): 129-33.
[http://dx.doi.org/10.1097/MNH.0b013e328040bfab] [PMID: 17293688]
[25]
Darimont C, Vassaux G, Ailhaud G, Negrel R. Differentiation of preadipose cells: paracrine role of prostacyclin upon stimulation of adipose cells by angiotensin-II. Endocrinology 1994; 135(5): 2030-6.
[http://dx.doi.org/10.1210/endo.135.5.7956925] [PMID: 7956925]
[26]
Jones BH, Standridge MK, Moustaid N. Angiotensin II increases lipogenesis in 3T3-L1 and human adipose cells. Endocrinology 1997; 138(4): 1512-9.
[http://dx.doi.org/10.1210/endo.138.4.5038] [PMID: 9075710]
[27]
Saint-Marc P, Kozak LP, Ailhaud G, Darimont C, Negrel R. Angiotensin II as a trophic factor of white adipose tissue: stimulation of adipose cell formation. Endocrinology 2001; 142(1): 487-92.
[http://dx.doi.org/10.1210/endo.142.1.7883] [PMID: 11145613]
[28]
Prusty D, Park BH, Davis KE, Farmer SR. Activation of MEK/ERK signaling promotes adipogenesis by enhancing peroxisome proliferator-activated receptor gamma (PPARgamma) and C/EBPalpha gene expression during the differentiation of 3T3-L1 preadipocytes. J Biol Chem 2002; 277(48): 46226-32.
[http://dx.doi.org/10.1074/jbc.M207776200] [PMID: 12270934]
[29]
Gatineau E, Cohn DM, Poglitsch M, Loria AS, Gong M, Yiannikouris F. Losartan prevents the elevation of blood pressure in adipose-PRR deficient female mice while elevated circulating sPRR activates the renin-angiotensin system. Am J Physiol Heart Circ Physiol 2019; 316(3): H506-15.
[http://dx.doi.org/10.1152/ajpheart.00473.2018] [PMID: 30550352]
[30]
Wang F, Luo R, Zou CJ, et al. Soluble (pro)renin receptor treats metabolic syndrome in mice with diet-induced obesity via interaction with PPARγ. JCI Insight 2020; 5(7): 128061.
[http://dx.doi.org/10.1172/jci.insight.128061] [PMID: 32271168]
[31]
Yin GS, Lin SD, Xu DC, Sun RQ, Lin K, Lin CJ. Handle region peptide ameliorating insulin resistance but not β cell functions in male rats neonatally treated with sodium L-glutamate. Int J Endocrinol 2013; 2013: 493828.
[http://dx.doi.org/10.1155/2013/493828] [PMID: 24385982]
[32]
Binger KJ, Neukam M, Tattikota SG, et al. Atp6ap2 deletion causes extensive vacuolation that consumes the insulin content of pancreatic β cells. Proc Natl Acad Sci USA 2019; 116(40): 19983-8.
[http://dx.doi.org/10.1073/pnas.1903678116] [PMID: 31527264]
[33]
Bonakdaran S, et al. Soluble (Pro) renin receptor is a predic-tor of gestational diabetes mellitus. Curr Diabetes Rev 2016; 13(6): 555-9.
[PMID: 27654965]
[34]
Gokulakrishnan K, Maheswari K, Mahalakshmi MM, et al. association of soluble (pro) renin receptor with gestational diabetes mellitus. Endocr Pract 2015; 21(1): 7-13.
[http://dx.doi.org/10.4158/EP14254.OR] [PMID: 25100397]
[35]
Watanabe N, Morimoto S, Fujiwara T, et al. Prediction of gestational diabetes mellitus by soluble (pro)renin receptor during the first trimester. J Clin Endocrinol Metab 2013; 98(6): 2528-35.
[http://dx.doi.org/10.1210/jc.2012-4139] [PMID: 23720787]
[36]
Nishijima T, Tajima K, Yamashiro Y, et al. Elevated plasma levels of soluble (Pro)renin receptor in patients with obstructive sleep apnea syndrome in parallel with the disease severity. Tohoku J Exp Med 2016; 238(4): 325-38.
[http://dx.doi.org/10.1620/tjem.238.325] [PMID: 27087286]
[37]
Gatineau E, Gong MC, Yiannikouris F. Soluble prorenin receptor increases blood pressure in high fat-fed male mice. Hypertension 2019; 74(4): 1014-20.
[http://dx.doi.org/10.1161/HYPERTENSIONAHA.119.12906] [PMID: 31378099]
[38]
Lu X, Meima ME, Nelson JK, et al. Identification of the (Pro)renin receptor as a novel regulator of low-density lipo-protein metabolism. Circ Res 2016; 118(2): 222-9.
[http://dx.doi.org/10.1161/CIRCRESAHA.115.306799] [PMID: 26582775]
[39]
Ren L, Sun Y, Lu H, et al. (Pro)renin receptor inhibition re-programs hepatic lipid metabolism and protects mice from diet-induced obesity and hepatosteatosis. Circ Res 2018; 122(5): 730-41.
[http://dx.doi.org/10.1161/CIRCRESAHA.117.312422] [PMID: 29301853]
[40]
Gatineau E, Arthur G, Poupeau A, et al. The prorenin receptor and its soluble form contribute to lipid homeostasis. Am J Physiol Endocrinol Metab 2021; 320(3): E609-18.
[http://dx.doi.org/10.1152/ajpendo.00135.2020] [PMID: 33459178]
[41]
Thyagarajan B, Foster MT. Beiging of white adipose tissue as a therapeutic strategy for weight loss in humans. Horm Mol Biol Clin Investig 2017; 31(2)
[http://dx.doi.org/10.1515/hmbci-2017-0016] [PMID: 28672737]
[42]
Tsai YS, Kim HJ, Takahashi N, et al. Hypertension and abnormal fat distribution but not insulin resistance in mice with P465L PPARgamma. J Clin Invest 2004; 114(2): 240-9.
[http://dx.doi.org/10.1172/JCI200420964] [PMID: 15254591]
[43]
Feldt S, Batenburg WW, Mazak I, et al. Prorenin and renin-induced extracellular signal-regulated kinase 1/2 activation in monocytes is not blocked by aliskiren or the handle-region peptide. Hypertension 2008; 51(3): 682-8.
[http://dx.doi.org/10.1161/HYPERTENSIONAHA.107.101444] [PMID: 18212269]
[44]
Muller DN, Klanke B, Feldt S, et al. (Pro)renin receptor peptide inhibitor “handle-region” peptide does not affect hypertensive nephrosclerosis in Goldblatt rats. Hypertension 2008; 51(3): 676-81.
[http://dx.doi.org/10.1161/HYPERTENSIONAHA.107.101493] [PMID: 18212268]
[45]
van Esch JH, van Veghel R, Garrelds IM, Leijten F, Bouhuizen AM, Danser AH. Handle region peptide counteracts the beneficial effects of the Renin inhibitor aliskiren in spontaneously hypertensive rats. Hypertension 2011; 57(4): 852-8.
[http://dx.doi.org/10.1161/HYPERTENSIONAHA.110.169060] [PMID: 21321303]
[46]
Wilkinson-Berka JL, Heine R, Tan G, et al. RILLKKMPSV influences the vasculature, neurons and glia, and (pro)renin receptor expression in the retina. Hypertension 2010; 55(6): 1454-60.
[http://dx.doi.org/10.1161/HYPERTENSIONAHA.109.148221] [PMID: 20368504]
[47]
Burcklé CA, Jan Danser AH, Müller DN, et al. Elevated blood pressure and heart rate in human renin receptor transgenic rats. Hypertension 2006; 47(3): 552-6.
[http://dx.doi.org/10.1161/01.HYP.0000199912.47657.04] [PMID: 16401765]
[48]
Li W, Peng H, Cao T, et al. Brain-targeted (pro)renin receptor knockdown attenuates angiotensin II-dependent hypertension. Hypertension 2012; 59(6): 1188-94.
[http://dx.doi.org/10.1161/HYPERTENSIONAHA.111.190108] [PMID: 22526255]
[49]
Li W, Peng H, Seth DM, Feng Y. The prorenin and (Pro)renin receptor: new players in the brain renin-angiotensin system? Int J Hypertens 2012; 2012: 290635.
[http://dx.doi.org/10.1155/2012/290635] [PMID: 23316344]
[50]
Li W, Sullivan MN, Zhang S, et al. Intracerebroventricular infusion of the (Pro)renin receptor antagonist PRO20 attenuates deoxycorticosterone acetate-salt-induced hypertension. Hypertension 2015; 65(2): 352-61.
[http://dx.doi.org/10.1161/HYPERTENSIONAHA.114.04458] [PMID: 25421983]
[51]
Shan Z, Shi P, Cuadra AE, et al. Involvement of the brain (pro)renin receptor in cardiovascular homeostasis. Circ Res 2010; 107(7): 934-8.
[http://dx.doi.org/10.1161/CIRCRESAHA.110.226977] [PMID: 20689062]
[52]
Choi YO, Park JH, Song YS, et al. Involvement of vesicular H+-ATPase in insulin-stimulated glucose transport in 3T3-F442A adipocytes. Endocr J 2007; 54(5): 733-43.
[http://dx.doi.org/10.1507/endocrj.K07-090] [PMID: 17827791]
[53]
Cruciat CM, Ohkawara B, Acebron SP, et al. Requirement of prorenin receptor and vacuolar H+-ATPase-mediated acidification for Wnt signaling. Science 2010; 327(5964): 459-63.
[http://dx.doi.org/10.1126/science.1179802] [PMID: 20093472]
[54]
Kinouchi K, Ichihara A, Sano M, et al. The (pro)renin receptor/ATP6AP2 is essential for vacuolar H+-ATPase assembly in murine cardiomyocytes. Circ Res 2010; 107(1): 30-4.
[http://dx.doi.org/10.1161/CIRCRESAHA.110.224667] [PMID: 20570919]
[55]
Ray BS. Of Wnt, prorenin receptor, and V-ATPase. Sci Signal 2010; 3(106): 29.
[http://dx.doi.org/10.1126/scisignal.3106ec29]
[56]
Riediger F, Quack I, Qadri F, et al. Prorenin receptor is essential for podocyte autophagy and survival. J Am Soc Nephrol 2011; 22(12): 2193-202.
[http://dx.doi.org/10.1681/ASN.2011020200] [PMID: 22034640]
[57]
Gao X, Zhang S, Wang D, Cheng Y, Jiang Y, Liu Y. (Pro)renin receptor contributes to hypoxia/reoxygenation-induced apoptosis and autophagy in myocardial cells via the beta-catenin signaling pathway. Physiol Res 2020; 69(3): 427-38.
[http://dx.doi.org/10.33549/physiolres.934210] [PMID: 32469229]
[58]
Reue K, Péterfy M. Mouse models of lipodystrophy. Curr Atheroscler Rep 2000; 2(5): 390-6.
[http://dx.doi.org/10.1007/s11883-000-0077-1] [PMID: 11122770]
[59]
Savage DB. Mouse models of inherited lipodystrophy. Dis Model Mech 2009; 2(11-12): 554-62.
[http://dx.doi.org/10.1242/dmm.002907] [PMID: 19892886]
[60]
Crane HM, Grunfeld C, Harrington RD, Kitahata MM. Lipoatrophy and lipohypertrophy are independently associated with hypertension. HIV Med 2009; 10(8): 496-503.
[http://dx.doi.org/10.1111/j.1468-1293.2009.00720.x] [PMID: 19486188]
[61]
Fahme SA, Bloomfield GS, Peck R. hypertension in hiv-infected adults: novel pathophysiologic mechanisms. Hypertension 2018; 72(1): 44-55.
[http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.10893] [PMID: 29776989]
[62]
Ramkumar N, Stuart D, Peterson CS, et al. loss of soluble (pro)renin receptor attenuates angiotensin-ii induced hypertension and renal injury. Circ Res 2021; 129(1): 50-62.
[http://dx.doi.org/10.1161/CIRCRESAHA.120.317532] [PMID: 33890822]
[63]
Wang F, Chen Y, Zou CJ, Luo R, Yang T. mutagenesis of the cleavage site of pro renin receptor abrogates angiotensin ii-induced hypertension in mice. Hypertension 2021; 78(1): 115-27.
[http://dx.doi.org/10.1161/HYPERTENSIONAHA.121.16770] [PMID: 34024121]
[64]
Fu Z, Wang F, Liu X, et al. Soluble (pro)renin receptor induces endothelial dysfunction and hypertension in mice with diet-induced obesity via activation of angiotensin II type 1 receptor. Clin Sci (Lond) 2021; 135(6): 793-810.
[http://dx.doi.org/10.1042/CS20201047] [PMID: 33625485]
[65]
Nguyen G, Blanchard A, Curis E, et al. Plasma soluble (pro)renin receptor is independent of plasma renin, prorenin, and aldosterone concentrations but is affected by ethnicity. Hypertension 2014; 63(2): 297-302.
[http://dx.doi.org/10.1161/HYPERTENSIONAHA.113.02217] [PMID: 24218434]
[66]
Song R, Kidd L, Janssen A, Yosypiv IV. Conditional ablation of the prorenin receptor in nephron progenitor cells results in developmental programming of hypertension. Physiol Rep 2018; 6(7): e13644.
[http://dx.doi.org/10.14814/phy2.13644] [PMID: 29611334]
[67]
Fukushima A, Kinugawa S, Homma T, et al. Increased plasma soluble (pro)renin receptor levels are correlated with renal dysfunction in patients with heart failure. Int J Cardiol 2013; 168(4): 4313-4.
[http://dx.doi.org/10.1016/j.ijcard.2013.04.176] [PMID: 23673200]
[68]
Morimoto S, Ando T, Niiyama M, et al. Serum soluble (pro)renin receptor levels in patients with essential hypertension. Hypertens Res 2014; 37(7): 642-8.
[http://dx.doi.org/10.1038/hr.2014.46] [PMID: 24646643]
[69]
Huber MJ, Basu R, Cecchettini C, Cuadra AE, Chen QH, Shan Z. Activation of the (pro)renin receptor in the paraventricular nucleus increases sympathetic outflow in anesthetized rats. Am J Physiol Heart Circ Physiol 2015; 309(5): H880-7.
[http://dx.doi.org/10.1152/ajpheart.00095.2015] [PMID: 26116710]
[70]
Nishijima T, Tajima K, Takahashi K, Sakurai S. Elevated plasma levels of soluble (pro)renin receptor in patients with obstructive sleep apnea syndrome: association with poly-somnographic parameters. Peptides 2014; 56: 14-21.
[http://dx.doi.org/10.1016/j.peptides.2014.03.008] [PMID: 24657284]
[71]
Takahashi K, Ohba K, Tajima K, Nishijima T, Sakurai S. Soluble (Pro)renin receptor and obstructive sleep apnea syndrome: oxidative stress in brain? Int J Mol Sci 2017; 18(6): E1313.
[http://dx.doi.org/10.3390/ijms18061313] [PMID: 28632190]
[72]
Seki Y, Yatabe M, Suda C, Morimoto S, Ichihara A. Elevated (Pro)renin receptor expression contributes to maintaining aerobic metabolism in growth hormone deficiency. J Endocr Soc 2018; 2(3): 252-65.
[http://dx.doi.org/10.1210/js.2017-00447] [PMID: 29594258]
[73]
Suda C, Yatabe J, Yatabe M, Yarita M, Ichihara A. Soluble (pro)renin receptor increased by hypoxia maintains oxidative metabolism in trophoblasts. J Mol Endocrinol 2020; 64(3): 145-54.
[http://dx.doi.org/10.1530/JME-19-0050] [PMID: 31958319]
[74]
Watanabe N, Morimoto S, Fujiwara T, et al. Association between soluble (Pro)renin receptor concentration in cord blood and small for gestational age birth: a cross-sectional study. PLoS One 2013; 8(3): e60036.
[http://dx.doi.org/10.1371/journal.pone.0060036] [PMID: 23555874]
[75]
Mikami Y, Takai Y, Narita T, et al. Associations between the levels of soluble (pro)renin receptor in maternal and umbilical cord blood and hypertensive disorder of pregnancy. Placenta 2017; 57: 129-36.
[http://dx.doi.org/10.1016/j.placenta.2017.06.342] [PMID: 28864001]
[76]
Watanabe N, Bokuda K, Fujiwara T, et al. Soluble (pro)renin receptor and blood pressure during pregnancy: a prospective cohort study. Hypertension 2012; 60(5): 1250-6.
[http://dx.doi.org/10.1161/HYPERTENSIONAHA.112.197418] [PMID: 23045457]
[77]
Narita T, Ichihara A, Matsuoka K, et al. Placental (pro)renin receptor expression and plasma soluble (pro)renin receptor levels in preeclampsia. Placenta 2016; 37: 72-8.
[http://dx.doi.org/10.1016/j.placenta.2015.11.007] [PMID: 26684753]

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