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摘要
在活细胞中,氧化还原电位对正常的生理过程至关重要,这些生理过程受到抗氧化剂、游离氨基酸和蛋白质的密切调控,这些蛋白质要么具有活性氧和氮捕获能力,要么可以被划分。尽管数以百计的实验支持自由基及其衍生物的调节作用,一些作者继续声称它们只发挥有害和非调节功能。在这篇文章中,我们证明了无数细胞内和细胞外的信号通路直接或间接地与被调控的氧化还原过程相关。我们还简要讨论了人工氧化应激如何可以有重要的治疗潜力和流行的抗氧化补充剂可能的负面影响。接下来,我们提出得到大量研究支持的论点,即先天免疫和发热的许多主要成分本质上与氧化还原过程有关。我们的目标是指出,由于受到干扰的细胞信号通路,过量或不受调控的自由基和活性物质的产生可能是次要过程。然而,药理学研究应考虑氧化还原机制在先天免疫系统和发热中的重要作用。
关键词: 氧化还原调节,先天免疫系统,发热,ROS, RNS, DNA。
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