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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Mini-Review Article

低强度电磁场通过电压门控钙通道（VGCC）激活诱发早期阿尔茨海默病：18种不同类型的证据

卷 19, 期 2, 2022

发表于: 11 March, 2022

页: [119 - 132] 页: 14

弟呕挨: 10.2174/1567205019666220202114510

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摘要

用电子方法产生的电磁场（EMF），与包括用于手机、Wi-Fi和智能仪表等的无线电的电磁场，是一致的。它会产生很高的电力和磁力，作用于电压门控钙通道的电压传感器上，引起细胞内钙[Ca2+]i的增加。阿尔茨海默病（AD）的钙假说表明每一个重要的AD特异性和非特异性诱发因素都是由于过高的[Ca2+]i引起的。[Ca2+]i通过过高的钙信号和过氧亚硝酸盐/氧化应激/炎症通道作用于AD。这些在EMFs作用下都有所升高。AD的一个明显的恶性循环涉及到β-淀粉样蛋白和[Ca2+]i。三种类型的流行病学都表明了EMF引发了AD，包括早期的AD。大量的动物模型研究表明低强度的EMFs会引起神经退化，包括AD。AD动物有着过高的Aβ、淀粉样前体蛋白和BACE1。据报道，每天暴露于脉冲EMFs中的大鼠成长为普遍或接近普遍的非常早期神经变性，包括AD。这些发现表面上与数字痴呆症患者类似。EMFs能引起[Ca2+]i的适度增加，也能产生保护、治疗的作用。治疗途径和过氧化亚硝酸盐途径相互抑制。对18种不同的发现进行总结，它们共同为EMFs与AD之间的因果关系提供了有力的证明。作者担心更智能、更高脉冲的无线通信可能会在人群中诱发广泛非常、非常早期的AD。

关键词: 阿尔茨海默病钙假说，非热电磁场效应，作为电磁场直接作用对象的电压传感器，阿尔茨海默病动物模型，EMF安全指导衰败、凋亡和自噬细胞的死亡，Aβ和[Ca2+]i恶性循环

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