Title:Zinc, Copper, Magnesium Levels in Polycystic Ovarian Syndrome Patients
Volume: 18
Issue: 5
Author(s): Simmi Kharb*, Chetna Bhatotiya, Shweta Gaur, Rajni Goel*, Aparna Khadelwal and Smiti Nanda*
Affiliation:
- Department of Biochemistry, Obstetrics & Gynecology, Pt. B. D. Sharma PGIMS, Rohtak, Haryana, India
- Department of Biochemistry, Obstetrics & Gynecology, Pt. B. D. Sharma PGIMS, Rohtak, Haryana, India
- Department of Biochemistry, Obstetrics & Gynecology, Pt. B. D. Sharma PGIMS, Rohtak, Haryana, India
Keywords:
PCOS, trace elements, serum zinc, serum copper, serum magnesium, BMI.
Abstract:
Background: Polycystic ovarian syndrome (PCOS) is one of the most common endocrine
diseases, and the status of trace elements is not clear.
Aims and Objectives: In the present cross-sectional study, the potential relationships between serum
levels of zinc, copper, magnesium, and PCOS were explored.
Materials and Methods: One hundred participants with PCOS and 100 healthy controls were
studied. They were in the age group (15-35 years) with the same socio-demographic characteristics.
Blood samples were drawn to estimate serum zinc, copper, and magnesium levels by autoanalyzer.
Results: Serum zinc and magnesium levels were found significantly higher among the study
group as compared to the control group. Serum copper levels were significantly lower in the
study group. Serum copper levels were significantly correlated with age and BMI among PCOS
women. Serum magnesium and zinc levels had a maximum area under the ROC curve, and the
high discriminating power of serum magnesium correlated with zinc levels for PCOS.
Conclusion: These results suggest that trace elements have a role in the pathogenesis of PCOS
and that supplementation may help manage the disease.
