Title:Resveratrol and Cervical Cancer: A New Therapeutic Option
Volume: 23
Issue: 2
Author(s): Rana Shafabakhsh, Russel J. Reiter, Michael Aschner, Hamed Mirzaei*Zatollah Asemi*
Affiliation:
- Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences,
Kashan, I.R. Iran
- Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences,
Kashan, I.R. Iran
Keywords:
Cervical cancer, resveratrol, therapy, molecular mechanism, pathology, natural compound.
Abstract: Globally, cervical cancer is the second most common cancer and the third main cause of
death related to cancer in women. The cervical cancer mortality rate is higher in underdeveloped and
developing vs. developed countries. Chronic infection with human papilloma virus (HPV) can trigger
cervical cancer by an interplay of a variety of pathways and molecules (i.e., inflammatory mediators,
oxidative stress and apoptosis), leading to carcinogenesis and cancer progression. Cervical carcinoma
is treatable in the early stages, while it progresses to metastasis at advanced stages; however, generally,
it is poorly manageable with current treatment options. For future advances in the treatment of
metastatic or recurrent cervical cancer carcinoma, the identification of new therapeutic platforms is
necessary. A new generation of drugs, herbs and spices may provide novel opportunities for cancer
therapy. Among the herb-based components, resveratrol has several beneficial effects given its anticancer
activities (e.g., anti-angiogenesis, anti-proliferation, anti-metastatic and pro-apoptotic). Hence,
this therapeutic agent may prove to have promising potential if clinically corroborated to possess anticancer
efficacy. Here, we summarize the chemopreventive and treatment actions of resveratrol for
cervical cancer as well as its mechanism of action.