Title:Protein Tyrosine Phosphatase 1B (PTP1B): Insights into its New Implications
in Tumorigenesis
Volume: 22
Issue: 3
关键词:
蛋白酪氨酸磷酸酶 (PTP)、蛋白酪氨酸磷酸酶 1B (PTP1B)、癌症、肿瘤启动子、肿瘤抑制因子、酪氨酸磷酸化。
摘要: In vivo, tyrosine phosphorylation is a reversible and dynamic process governed by the opposing
activities of protein tyrosine kinases and phosphatases. Defective or inappropriate operation
of these proteins leads to aberrant tyrosine phosphorylation, which contributes to the development of
many human diseases, including cancers. PTP1B, a non-transmembrane phosphatase, is generally
considered a negative regulator of the metabolic signaling pathways and a promising drug target for
type II diabetes and obesity. Recently, PTP1B is gaining considerable interest due to its important
function and therapeutic potential in other diseases. An increasing number of studies have indicated
that PTP1B plays a vital role in the initiation and progression of cancers and could be a target for
new cancer therapies. Following recent advances in the aspects mentioned above, this review is focused
on the major functions of PTP1B in different types of cancer and the underlying mechanisms
behind these functions, as well as the potential pharmacological effects of PTP1B inhibitors in cancer
therapy.
