Title:Transdermal Anti-inflammatory Delivery for Solid Lipid Nanoparticles of
Ketoprofen by Microwave-assisted Microemulsion
Volume: 15
Issue: 2
Author(s): Swati C. Jagdale*, Manisha S. Bafna and Anuruddha R. Chabukswar
Affiliation:
- School of Pharmacy, Dr. Vishwanath Karad MIT World Peace University, MIT Campus, Kothrud, Pune, MH,
411038, India
Keywords:
Solid lipid nanoparticles, ketoprofen, microwave, delivery, microemulsion, transdermal.
Abstract:
Aims: To prepare solid lipid nanopaticles (SLNs) of Ketoprofen (KP) using microwave
method. Ketoprofen (KP) is 2-(3-benzolphenyl) propionic acid with anti-inflammatory, analgesic
and antipyretic property. The drug has a short half-life of 120 mins. It belongs to BCS Class II
drug. Gastric irritation is a major limitation for delivery because of acidic nature of the drug. The
development of solid lipid nanoparticles with its transdermal drug delivery was the aim of the present
work.
Methods: Microwave-assisted microemulsion technique was used for the development of solid
lipid nanoparticles. Stearic acid was used as lipid and tween 80 was used as a surfactant. By varying
the type of lipid and input energy watt, batches were formulated. SLNs were evaluated for zeta
potential, drug entrapment, particle size and in-vitro drug release. Crystallinity behaviour was determined
by differential scanning calorimetry and powder X-ray diffraction. Anti-inflammatory activity
was evaluated for batch M4 of SLNs. The gel was prepared for M4 batch. It was evaluated for
viscosity, pH, drug content, in-vitro and ex-vivo diffusion study.
Results: SLNs were developed successfully. Based on the size, entrapment efficiency, stability and
drug release, batch M4 was selected. SLNs showed 74.8% entrapment efficiency. Forty-fold improvement
was observed in the solubility. The particle size was 682.9 nm and average size 1047
nm. PDI was 0.685 and zeta potential was -29.5 mV. M4 SLNs batch of gel showed burst release
followed by a controlled release for 8 hrs in in-vitro drug release.
Conclusion: SLNs were successfully prepared by Microwave-assisted microemulsion technique.
SLNs with anti-inflammatory activity were successfully developed with their transdermal delivery.
