Title:The Role of LncRNA TUG1 in Obesity-related Diseases
Volume: 22
Issue: 9
Author(s): Mengzhen Xue, Fangqi Xia, Yaqi Wang, Leiqi Zhu, Yuanyang Li, Dengke Jia, Yan Gao, Yue Shi, Changcheng Zhang, Yumin He, Chaoqi Liu, Ding Yuan*Chengfu Yuan*
Affiliation:
- College of Medical Science, China Three Gorges University, Yichang 443002, China
- Third-Grade Pharmacological
Laboratory on Chinese Medicine Approved by State Administration of Traditional Chinese Medicine, Medical College
of China Three Gorges, Yichang. Hubei 443002. China
- College of Medical Science, China Three Gorges University, Yichang 443002, China
- Third-Grade Pharmacological
Laboratory on Chinese Medicine Approved by State Administration of Traditional Chinese Medicine, Medical College
of China Three Gorges, Yichang. Hubei 443002. China
- Hubei Key Laboratory of Tumour Microenvironment and Immunotherapy,
China Three Gorges University, Yichang, China
Keywords:
Long non-coding RNA, TUG1, diseases related to obesity, obesity, exosomes, molecular mechanism.
Abstract: As the living standards of people are increasingly improved, obesity has become a hotspot
in our daily life. Obesity has been found as a chronic and recurrent disease with serious adverse consequences.
Over the past few years, several articles indicated that long non-coding RNA taurine increased
gene 1 (lncRNA TUG1), a useful RNA, which was indicated to show a relationship to obesity-
related disease occurrence and development. Exosomes are recognized as an emerging research
field that includes substances actively involved in regulating the molecular mechanisms of disease.
This review summarizes the current relevant TUG1 in different molecular pathways of obesityassociated
diseases, the correlation between exosomes and TUG1, or obesity-associated diseases. The
aim is to explore TUG1 as a novel target for obesity, which can deepen the knowledge regarding the
epigenetic regulation pathway. Furthermore, it is expected to focus on diseases associated with obesity
treatment and diagnosis.